Original Research

Cellular and Molecular Neurobiology

, Volume 25, Issue 6, pp 973-980

Enhanced BDNF Signaling is Associated with an Antidepressant-like Behavioral Response and Changes in Brain Monoamines

  • Eija KoponenAffiliated withDepartment of Neurobiology, A.I. Virtanen Institute, University of Kuopio
  • , Tomi RantamäkiAffiliated withNeuroscience Center, University of Helsinki
  • , Vootele VoikarAffiliated withNeuroscience Center, University of Helsinki
  • , Tommi SaarelainenAffiliated withDepartment of Neurobiology, A.I. Virtanen Institute, University of Kuopio
  • , Ewen MacDonaldAffiliated withPharmacology and Toxicology, University of Kuopio
  • , Eero CastrénAffiliated withNeuroscience Center, University of Helsinki Email author 

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Summary

  1. 1.

    Neurotrophins and serotonin have both been implicated in the pathophysiology of depression and in the mechanisms of antidepressant treatments.

     
  2. 2.

    Brain-derived neurotrophic factor (BDNF) influences the growth and plasticity of serotonergic (5-HT) neurons via the activation of trkB receptor.

     
  3. 3.

    Transgenic mice overexpressing the full-length trkB receptor (TrkB.TK+) and showing increased trkB activity in brain, and their wild type (WT) littermates, were injected with the antidepressant fluoxetine or saline, and analyzed behaviorally in the forced swimming test paradigm and biochemically for the concentrations of brain monoamines and their metabolites.

     
  4. 4.

    The TrkB.TK+ mice displayed increased latency to immobility in the forced swim test, suggesting resistance to behavioral despair.

     
  5. 5.

    Fluoxetine increased the latency to immobility in wild-type mice to a similar level as seen in the trkB.TK+ mice after saline treatment, but had no further behavioral effect in the swimming behavior of the trkB.TK+ mice.

     
  6. 6.

    Only minor differences in the levels of brain monoamines and their metabolites were observed between the transgenic and wild-type mice.

     
  7. 7.

    These data, together with other recent observations, suggest that trkB activation may play a critical role in the behavioral responses to antidepressant drugs in mice.

     

Key Words

BDNF trkB neurotrophin serotonin norepinephrine hippocampus cingulate cortex