Cellular and Molecular Neurobiology

, Volume 24, Issue 6, pp 873–875

Toxicity of Quinacrine Can Be Reduced By Co-Administration of P-Glycoprotein Inhibitor in Sporadic Creutzfeldt-Jakob Disease

  • Katsuya Satoh
  • Susumu Shirabe
  • Katsumi Eguchi
  • Atsushi Yamauchi
  • Yasufumi Kataoka
  • Masami Niwa
  • Noriyuki Nishida
  • Shigeru Katamine
Article

DOI: 10.1007/s10571-004-6926-7

Cite this article as:
Satoh, K., Shirabe, S., Eguchi, K. et al. Cell Mol Neurobiol (2004) 24: 873. doi:10.1007/s10571-004-6926-7

Abstract

1. Recent publication has suggested that quinacrine may be a candidate for treatment of Creutzfeldt-Jakob disease (CJD). But serious toxicity of quinacrine to liver and hematological system has been reported.

2. We disclosed the permeability of quinacrine can be enhanced by presence of p-glycoprotein inhibitor at blood–brain barrier in vitro. Therefore, we tried the protocol of combination of quinacrine and p-glycoprotein inhibitor, verapamil for patients with CJD.

3. When compared clinical effects by quinacrine and the combination therapy, improvement of clinical findings was observed at the same level without any adverse effects. Low-dose quinacrine with verapamil can be used as safe treatment of CJD.

quinacrine sporadic Creutzfeldt-Jakob disease p-glycoprotein inhibitor 

Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Katsuya Satoh
    • 1
  • Susumu Shirabe
    • 1
  • Katsumi Eguchi
    • 1
  • Atsushi Yamauchi
    • 2
  • Yasufumi Kataoka
    • 2
  • Masami Niwa
    • 3
  • Noriyuki Nishida
    • 4
  • Shigeru Katamine
    • 4
  1. 1.The First Department of Internal MedicineNagasaki University Graduate School of Biomedical ScienceNagasakiJapan
  2. 2.Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical SciencesFukuoka UniversityJo-nan kuJapan
  3. 3.Department of PharmacologyNagasaki University Graduate School of Biomedical ScienceNagasakiJapan
  4. 4.Department of Molecular Microbiology and ImmunologyNagasaki University Graduate School of Biomedical ScienceNagasakiJapan

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