Cell and Tissue Banking

, Volume 13, Issue 4, pp 569–575

Establishing a cGMP pancreatic islet processing facility: the first experience in Iran

Authors

  • Bagher Larijani
    • Endocrinology and Metabolism Research CenterTehran University of Medical Sciences, Shariati Hospital
  • Babak Arjmand
    • Endocrinology and Metabolism Research CenterTehran University of Medical Sciences, Shariati Hospital
    • Brain and Spinal Cord Injury Repair Research CenterTehran University of Medical Sciences, Imam Khomeini Hospital
  • Mahsa M. Amoli
    • Endocrinology and Metabolism Research CenterTehran University of Medical Sciences, Shariati Hospital
  • Ziliang Ao
    • Human Islet Isolation LaboratoryThe University of British Colombia
  • Ali Jafarian
    • Department of Liver TransplantationImam Khomeini Hospital
  • Mitra Mahdavi-Mazdah
    • Department of nephrology and Iranian Tissue BankImam Khomeini Hospital, Tehran University of Medical Sciences
  • Hossein Ghanaati
    • Department of RadiologyMedical Imaging Center, Imam Khomeini Hospital
  • Reza Baradar-Jalili
    • Department of SurgeryUniversity of British Columbia
  • Sasan Sharghi
    • Endocrinology and Metabolism Research CenterTehran University of Medical Sciences, Shariati Hospital
  • Abbas Norouzi-Javidan
    • Brain and Spinal Cord Injury Repair Research CenterTehran University of Medical Sciences, Imam Khomeini Hospital
    • Endocrinology and Metabolism Research CenterTehran University of Medical Sciences, Shariati Hospital
    • Brain and Spinal Cord Injury Repair Research CenterTehran University of Medical Sciences, Imam Khomeini Hospital
Article

DOI: 10.1007/s10561-011-9273-1

Cite this article as:
Larijani, B., Arjmand, B., Amoli, M.M. et al. Cell Tissue Bank (2012) 13: 569. doi:10.1007/s10561-011-9273-1

Abstract

It has been predicted that one of the greatest increase in prevalence of diabetes will happen in the Middle East bear in the next decades. The aim of standard therapeutic strategies for diabetes is better control of complications. In contrast, some new strategies like cell and gene therapy have aimed to cure the disease. In recent years, significant progress has occurred in beta-cell replacement therapies with a progressive improvement of short-term and long term outcomes. In year 2005, considering the impact of the disease in Iran and the promising results of the Edmonton protocol, the funding for establishing a current Good Manufacturing Practice (cGMP) islet processing facility by Endocrinology and Metabolism Research Center was approved by Tehran University of Medical Sciences. Several islet isolations were performed following establishment of cGMP facility and recruitment of all required equipments for process validation and experimental purpose. Finally the first successful clinical islet isolation and transplantation was performed in September 2010. In spite of a high cost of the procedure it is considered beneficial and may prevent long term complications and the costs associated with secondary cares. In this article we will briefly describe our experience in setting up a cGMP islet processing facility which can provide valuable information for regional countries interested to establish similar facilities.

Keywords

Clean roomClinical gradecGMPPancreatic islet

Copyright information

© Springer Science+Business Media B.V. 2011