Article

Cell and Tissue Banking

, Volume 12, Issue 2, pp 105-110

First online:

Adeno-associated virus (AAV) based gene therapy for eye diseases

  • Shuang WangAffiliated withDepartment of Ophthalmology, The Second Hospital of Ji Lin UniversityChina-Japan Union Hospital of Jilin University
  • , Peng LiuAffiliated withChina-Japan Union Hospital of Jilin University
  • , Lei SongAffiliated withDepartment of Neurology, The First Hospital of Ji Lin University
  • , Lei LuAffiliated withDepartment of Neurology, The First Hospital of Ji Lin University
  • , Wensong ZhangAffiliated withDepartment of Neurology, The First Hospital of Ji Lin University
  • , Yazhen WuAffiliated withDepartment of Ophthalmology, The Second Hospital of Ji Lin University Email author 

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Abstract

Gene therapy emerged as important approach in treatment for many inborn disorders caused by genetic defects, as well as other diseases. This manuscript focused on Adeno-associated virus (AAV) based gene therapy to eye diseases. The paper firstly introduced the AAV vectors and the techniques of eye delivery, then summarized some tested genes that were used in past treatment to retinal degeneration disorders. Finally the paper discussed the updated optogenetics and its roles in AAV based gene therapy for eye diseases.

Keywords

AAV Gene therapy Optogenetics Neovascularization Trophic factor Neuroprotection