Cell and Tissue Banking

, Volume 8, Issue 4, pp 303–305

Evaluation of tissue discards after implementation of anti-HBc test in a tissue bank in Spain

  • Rafael Villalba
  • Gema Fornés
  • Marcela Eisman
  • Jose Luis Gómez Villagrán
Brief Communication

DOI: 10.1007/s10561-007-9039-y

Cite this article as:
Villalba, R., Fornés, G., Eisman, M. et al. Cell Tissue Banking (2007) 8: 303. doi:10.1007/s10561-007-9039-y


The recent introduction as a minimum test required in The Guide to Safety and Quality Assurance for Organs, Tissues and Cells (Council Europe) and the Directive 2004/23/EC applied to donation, procurement, testing, processing, preservation, storage and distribution of human cells and tissues make necessary the implementation of these markers in all European Tissue Establishments. In this study we have analyzed the impact in tissues discard by introducing anti-HBc in a European Tissue Establishment in a country with a high prevalence of HBV infection. The adoption of this exclusion criteria in this region results in acceptably rejection rates among tissue donors, although some studies are needed on basis a risk assessment to determine the eligibility for clinical use.


Hepatitis BTissue transplantationSafetyTesting



Hepatitis B virus


Hepatitis C virus


Human immunodeficiency virus

HBs Ag

Hepatitis B surface antigen


Hepatitis B core


Nucleic acid test

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Rafael Villalba
    • 1
  • Gema Fornés
    • 1
  • Marcela Eisman
    • 1
  • Jose Luis Gómez Villagrán
    • 1
  1. 1.Centro Regional de Transfusión Sanguínea y Banco Sectorial de TejidosCordobaSpain