, Volume 28, Issue 1, pp 1-3
Date: 15 Oct 2013

Transferring Protection: Adenosine as the Lone Ranger?

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Coronary effluent from a heart undergoing brief periods of ischemia and reperfusion that leads to the cytoprotection of ischemic preconditioning decreases injury when administered before ischemia to a second heart; the “transfer of cardioprotection” phenomena [1]. In the current issue of Cardiovascular Drugs and Therapy, Dr. Leung and colleagues replicate the “transfer of cardioprotection” in an isolated rabbit heart model [2]. The authors hypothesize that increased adenosine content in coronary effluent from the first ischemic preconditioned heart is the key mediator of the protection transferred to the second heart. Four lines of evidence support their hypothesis: (1) the content of adenosine in collected coronary effluent from preconditioned hearts is dramatically increased; (2) the phenomena of “transfer protection” is blocked by a non-selective adenosine receptor inhibitor; (3) direct addition of adenosine into coronary effluent from non-preconditioned hearts provides a similar re