Cardiovascular Drugs and Therapy

, Volume 24, Issue 1, pp 17-24

First online:

Aspirin Inhibits Fractalkine Expression in Atherosclerotic Plaques and Reduces Atherosclerosis in ApoE Gene Knockout Mice

  • Hong LiuAffiliated withDepartment of Geriatrics, The Second Xiangya Hospital of Central South University Email author 
  • , Deqian JiangAffiliated withDepartment of Cardiology, The Second Xiangya Hospital of Central South University
  • , Shebing ZhangAffiliated withDepartment of Cardiology, The Affiliated Yue Bei People’s Hospital of Shantou University Medical College
  • , Baiqing OuAffiliated withDepartment of Cardiology, The Hunan People’s Hospital

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To determine the fractalkine expression in the aorta of ApoE −/− mice and the effect of high-dose aspirin intervention on fractalkine expression and atherosclerotic lesion formation.


Twenty-one male ApoE gene knockout mice were randomized into three groups to receive either placebo in addition to normal mice chow (n = 7), placebo in addition to a high-fat diet (n = 7), or aspirin (58 mg/kg/d) in addition to a high-fat diet (n = 7). After 12 weeks of study, the mice were euthanized and serum cholesterol, thromboxane B2, and \( 6 - {\text{keto}} - {\text{PG}}{{\text{F}}_{1\alpha }} \) were examined. Fractalkine and cyclooxygenase expression in aorta were measured and the atherosclerotic lesion analyzed.


Pathology image analysis showed that the atherosclerotic plaque was the most extensive in the high-fat diet group while the addition of aspirin greatly reduced the severity of the plaque. Both RT-PCR analysis and immunohistochemical analysis showed that fractalkine expression was the strongest in the high-fat diet group and was significantly decreased by aspirin treatment. Serum thromboxane B2 was lowered by aspirin while \( 6 - {\text{keto}} - {\text{PG}}{{\text{F}}_{1\alpha }} \) and cholesterol remained unchanged.


The results of our study indicate that high dose aspirin can improve the atherosclerotic lesion and suppress the fractalkine expression in murine aorta.

Key words

Aspirin Atherosclerosis Fractalkine Cyclooxygenase