, Volume 23, Issue 6, pp 425-429,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 25 Nov 2009

Resveratrol: A Multifunctional Compound Improving Endothelial Function


The red wine polyphenol resveratrol boosts endothelium-dependent and -independent vasorelaxations. The improvement of endothelial function by resveratrol is largely attributable to nitric oxide (NO) derived from endothelial NO synthase (eNOS). By stimulating eNOS expression, eNOS phosphorylation and eNOS deacetylation, resveratrol enhances endothelial NO production. By upregulating antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and suppressing the expression and activity of NADPH oxidases, resveratrol inhibits superoxide-mediated NO inactivation. Some resveratrol effects are mediated by sirtuin 1 (SIRT1) or estrogen receptors, respectively.

An erratum to this article can be found at http://dx.doi.org/10.1007/s10557-010-6218-z