Cardiovascular Drugs and Therapy

, 23:471

Statin Use is Associated with a Significant Reduction in Cholesterol Content of Erythrocyte Membranes. A Novel Pleiotropic Effect?

Authors

    • University Cardiology Department, Medical SchoolDemocritus University of Thrace
  • Georgios K. Chalikias
    • University Cardiology Department, Medical SchoolDemocritus University of Thrace
  • Dimitrios Stakos
    • University Cardiology Department, Medical SchoolDemocritus University of Thrace
  • Ioannis K. Tentes
    • Biochemistry Department, Medical SchoolDemocritus University of Thrace
  • Adina Thomaidi
    • University Cardiology Department, Medical SchoolDemocritus University of Thrace
  • Sofia Chatzikyriakou
    • University Cardiology Department, Medical SchoolDemocritus University of Thrace
  • Konstantina Mitrousi
    • University Cardiology Department, Medical SchoolDemocritus University of Thrace
  • Alexandros X. Kortsaris
    • Biochemistry Department, Medical SchoolDemocritus University of Thrace
  • Juan Carlos Kaski
    • Cardiovascular Biology Research Centre, St George’s HospitalUniversity of London
  • Harisios Boudoulas
    • Center for Clinical Research, Foundation of Biomedical ResearchAcademy of Athens
  • Stavros Konstantinides
    • University Cardiology Department, Medical SchoolDemocritus University of Thrace
Article

DOI: 10.1007/s10557-009-6202-7

Cite this article as:
Tziakas, D.N., Chalikias, G.K., Stakos, D. et al. Cardiovasc Drugs Ther (2009) 23: 471. doi:10.1007/s10557-009-6202-7

Abstract

Purpose

High cholesterol content of erythrocyte membranes (CEM) levels is present in patients with acute coronary syndromes (ACS). Intraplaque hemorrhage and erythrocyte lysis contribute to the deposition of cholesterol on the atherosclerotic plaque and to plaque rupture. With the present study we assessed the effect of statin therapy on CEM levels, a novel marker of coronary artery disease (CAD) instability during a 1-year follow-up in CAD patients.

Methods

212 consecutive eligible (158 men, 62 ± 10 years) patients undergoing diagnostic coronary angiography for the assessment of angina pectoris were assessed. The study population comprised of 84 chronic stable angina (CSA) patients and 128 ACS patients. All study participants were commenced on statin treatment in equipotent doses and were followed for up to 1 year (at  − 1,  − 3,  − 6 and  − 12 months).

Results

Repeated measurements analysis of variance after appropriate adjustment showed a significant decrease (p < 0.001) in CEM content during follow up. CEM levels were decreasing at each time point (1 month : 100 ug/mg 95%CI 94.3–105.6, 3 months : 78.1 ug/mg 95%CI 73.2–83, 6 months : 67.2 ug/mg 95%CI 63.1–71.2, 1 year : 45.3 ug/mg 95%CI 42.2–48.3) compared to admission (112.1 ug/mg 95% CI 105.9–118.3) and to all previous measurements.

Conclusions

The present study showed, that use of statins is associated with a reduction in CEM, an emerging marker of clinical instability and plaque vulnerability in CAD patients. The pleiotropic effects of statins at the cell membrane level represent a promising novel direction for research in CAD.

Key words

Erythrocyte membranesCholesterol contentStatinsCoronary artery disease

Copyright information

© Springer Science+Business Media, LLC 2009