, Volume 23, Issue 1, pp 25-29
Date: 19 Nov 2008

Clinical Trials Update from the European Society of Cardiology Congress in Munich, 2008: TIME-CHF, CARESS-in-AMI, TRITON-TIMI 38, EUROPA, AF-CHF, and ADVANCE

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Presented by H.P. Brunner-La Rocca from Basel, Switzerland

Background: The TIME-CHF study was designed to evaluate the potential utility of monitoring of plasma N-terminal brain natriuretic peptide (NT-BNP) levels as an adjunct to therapy for chronic heart failure in ageing individuals. The study addresses in particular the paucity of information about the relationship between manipulating of NT-BNP concentrations and outcomes in very elderly patients who constitute a substantial proportion of most chronic heart failure populations.

Methods: A prospective, single-blinded randomised single-centre study was conducted in 49 patients with symptomatic CHF, including related hospitalisation within the previous year. Randomisation, stratified according to patients’ age (60–74 vs 75 + years) was either to standard therapy or to an intensified regimen directed to reduce plasma NT-BNP concentrations, as a marker of improved CHF control. The primary end-point was hospitalisation-free surviv ...