Cardiovascular Drugs and Therapy

, Volume 20, Issue 5, pp 365–375

Highly Purified Omega-3 Fatty Acids for Secondary Prevention of Sudden Cardiac Death After Myocardial Infarction—Aims and Methods of the OMEGA-Study

  • Bernhard Rauch
  • Rudolf Schiele
  • Steffen Schneider
  • Helmut Gohlke
  • Frank Diller
  • Martin Gottwik
  • Gerhard Steinbeck
  • Tobias Heer
  • Hugo Katus
  • Reinhilde Zimmer
  • Ali Erdogan
  • Conrad Pfafferott
  • Jochen Senges for the OMEGA-Study Group
Study Design

DOI: 10.1007/s10557-006-0495-6

Cite this article as:
Rauch, B., Schiele, R., Schneider, S. et al. Cardiovasc Drugs Ther (2006) 20: 365. doi:10.1007/s10557-006-0495-6

Abstract

Introduction

During the last decades a large body of data has been accumulated indicating omega-3 fatty acids to exert beneficial effects on the prognosis of patients with cardiovascular disease. Especially, omega-3 fatty acids are regarded to be effective in reducing the risk of sudden cardiac death after acute myocardial infarction. However, treatment of acute myocardial infarction and secondary prevention considerably have been improved within the past years including early revascularization by PCI, the routine use of beta-blockers, statins and ACE-inhibitors as well as cardiac rehabilitation for improving life style measures. To date, there exists no controlled randomized trial testing the prognostic effect of omega-3 fatty acids after acute myocardial infarction in a double blind regimen under the conditions of modern treatment of myocardial infarction.

Materials and methods

The present study therefore evaluates the effect of highly purified omega-3 fatty acid ethylesters (omega-3-acid ethyl esters 90=Zodin®) on the rate of sudden cardiac death within 1 year after acute myocardial infarction. Secondary endpoints are total mortality, non-fatal cardiovascular events, rhythm abnormalities in holter monitoring and depression score.

Result and conclusion

The recruitment-period started in October 2003 and is expected to last until December 2006. The results of the study are therefore expected for the beginning of 2008, when all patients will have completed the 12-months follow up-period.

Key words

myocardial infarction omega-3 fatty acids omega-3-acid ethyl esters 90 secondary prevention sudden cardiac death Holter monitoring depression Beck depression inventory 

Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Bernhard Rauch
    • 1
    • 2
  • Rudolf Schiele
    • 1
  • Steffen Schneider
    • 2
  • Helmut Gohlke
    • 3
  • Frank Diller
    • 2
  • Martin Gottwik
    • 4
  • Gerhard Steinbeck
    • 5
  • Tobias Heer
    • 1
  • Hugo Katus
    • 6
  • Reinhilde Zimmer
    • 7
  • Ali Erdogan
    • 8
  • Conrad Pfafferott
    • 9
  • Jochen Senges for the OMEGA-Study Group
    • 1
  1. 1.HerzzentrumKlinikum der Stadt LudwigshafenLudwigshafenGermany
  2. 2.Stiftung Institut für HerzinfarktforschungLudwigshafenGermany
  3. 3.Herzzentrum Bad KrozingenBad KrozingenGermany
  4. 4.Med. Klinik 8Klinikum Nürnberg SüdNürnbergGermany
  5. 5.Med. Klinik und Poliklinik IKlinikum GroßhadernMünchenGermany
  6. 6.Medizinische Klinik IIIUniversitätsklinikum HeidelbergHeidelbergGermany
  7. 7.Klinik für Psychiatrie und PsychotherapieKlinikum r. d. IsarMünchenGermany
  8. 8.Zentrum für Innere Med. IUniversitätsklinikum GießenGießenGermany
  9. 9.Med. Klinik IKlinikum IngolstadtIngolstadtGermany

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