Cancer and Metastasis Reviews

, Volume 33, Issue 1, pp 101–113

Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer

  • Suh Youn Ko
  • Gregory L. Blatch
  • Crispin R. Dass
NON-THEMATIC REVIEW

DOI: 10.1007/s10555-013-9459-z

Cite this article as:
Ko, S.Y., Blatch, G.L. & Dass, C.R. Cancer Metastasis Rev (2014) 33: 101. doi:10.1007/s10555-013-9459-z

Abstract

Despite advanced screening technology and cancer treatments available today, metastasis remains an ongoing major cause of cancer-related deaths worldwide. Typically, colorectal cancer is one of the cancers treatable by surgery in conjunction with chemotherapy when it is detected at an early stage. However, it still ranks as the second highest modality and mortality of cancer types in western countries, and this is mostly due to a recurrence of metastatic colorectal cancer post-resection of the primary malignancy. Colorectal cancer metastases predominantly occur in the liver and lung, and yet the molecular mechanisms that regulate these organ-specific colorectal cancer metastases are largely unknown. Therefore, the identification of any critical molecule, which triggers malignancy in colorectal cancer, would be an excellent target for treatment. Netrin-1 was initially discovered as a chemotropic neuronal guidance molecule, and has been marked as a regulator for many cancers including colorectal cancer. Here, we summarise key findings of the role of netrin-1 intrinsic to colorectal cancer cells, extrinsic to the tumour microenvironment and angiogenesis, and consequently, we evaluate netrin-1 as a potential target molecule for metastasis.

Keywords

Metastasis Colorectal cancer Netrin-1 Netrin-1 receptors Angiogenesis Microenvironment 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Suh Youn Ko
    • 1
  • Gregory L. Blatch
    • 1
  • Crispin R. Dass
    • 2
  1. 1.College of Health and BiomedicineVictoria UniversitySt AlbansAustralia
  2. 2.School of PharmacyCurtin UniversityBentleyAustralia