Cancer and Metastasis Reviews

, Volume 32, Issue 3, pp 501–509

Dormancy in solid tumors: implications for prostate cancer

Authors

  • Nazanin S. Ruppender
    • Department of UrologyUniversity of Washington
  • Colm Morrissey
    • Department of UrologyUniversity of Washington
  • Paul H. Lange
    • Department of Veterans AffairsVA Medical Center
    • Department of UrologyUniversity of Washington
    • Department of Veterans AffairsVA Medical Center
    • Department of UrologyUniversity of Washington
NON-THEMATIC REVIEW

DOI: 10.1007/s10555-013-9422-z

Cite this article as:
Ruppender, N.S., Morrissey, C., Lange, P.H. et al. Cancer Metastasis Rev (2013) 32: 501. doi:10.1007/s10555-013-9422-z

Abstract

In cancer dormancy, residual tumor cells persist in a patient with no apparent clinical symptoms, only to potentially become clinically relevant at a later date. In prostate cancer (PCa), the primary tumor is often removed and many patients experience a prolonged period (>5 years) with no evidence of disease before recurrence. These characteristics make PCa an excellent candidate for the study of tumor cell dormancy. However, the mechanisms that constitute PCa dormancy have not been clearly defined. Additionally, the definition of tumor cell dormancy varies in the literature. Therefore, we have separated tumor cell dormancy in this review into three categories: (a) micrometastatic dormancy—a group of tumor cells that cannot increase in number due to a restrictive proliferation/apoptosis equilibrium. (b) Angiogenic dormancy—a group of tumor cells that cannot expand beyond the formation of a micrometastasis due to a lack of angiogenic potential. (c) Conditional dormancy—an individual cell or a very small number of cells that cannot proliferate without the appropriate cues from the microenvironment, but do not require angiogenesis to do so. This review aims to identify currently known markers, mechanisms, and models of tumor dormancy, in particular as they relate to PCa, and highlight current opportunities for advancement in our understanding of clinical cancer dormancy.

Keywords

DormancyDisseminated tumor cellsProstate cancerMetastasis

Abbreviations

CRPC

Castration-resistant prostate cancer

CTC

Circulating tumor cell

DTC

Disseminated tumor cells

PCa

Prostate cancer

PSA

Prostate-specific antigen

Copyright information

© Springer Science+Business Media New York 2013