Cancer and Metastasis Reviews

, Volume 31, Issue 3, pp 553–568

TGF-β signalling and its role in cancer progression and metastasis

Authors

    • Department of Molecular Cell Biology and Centre for Biomedical GeneticsLeiden University Medical Center
  • Peter ten Dijke
    • Department of Molecular Cell Biology and Centre for Biomedical GeneticsLeiden University Medical Center
    • Uppsala University and Ludwig Institute for Cancer Research
Article

DOI: 10.1007/s10555-012-9375-7

Cite this article as:
Drabsch, Y. & ten Dijke, P. Cancer Metastasis Rev (2012) 31: 553. doi:10.1007/s10555-012-9375-7

Abstract

The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and SMAD mediators to regulate a large number of biological processes. Alterations of the TGF-β signalling pathway are implicated in human cancer. Prior to tumour initiation and early during progression, TGF-β acts as a tumour suppressor; however, at later stages, it is often a tumour promoter. Knowledge about the mechanisms involved in TGF-β signal transduction has allowed a better understanding of cancer progression, invasion, metastasis and epithelial-to-mesenchymal transition. Furthermore, several molecular targets with great potential in therapeutic interventions have been identified. This review discusses the TGF-β signalling pathway, its involvement in cancer and current therapeutic approaches.

Keywords

TGF-β signallingSMADCancerEpithelial to mesenchymal transition

Copyright information

© Springer Science+Business Media, LLC 2012