Cancer and Metastasis Reviews

, Volume 31, Issue 3, pp 585–591

KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis

  • Sung-Gook Cho
  • Dali Li
  • Kunrong Tan
  • Stefan K. Siwko
  • Mingyao Liu
Article

DOI: 10.1007/s10555-012-9367-7

Cite this article as:
Cho, SG., Li, D., Tan, K. et al. Cancer Metastasis Rev (2012) 31: 585. doi:10.1007/s10555-012-9367-7

Abstract

KiSS1 and its cognate G-protein-coupled receptor, GPR54, have diverse functions. While KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still unclear. In cancer, KiSS1 and GPR54 have been known to suppress metastasis by inhibiting cancer cell motility. However, recent studies suggest that KiSS1 and GPR54 have varied roles even in cancer development and metastasis. Here, we examine recent advances in understanding the roles of KiSS1 and GPR54 in cancer development and metastasis.

Keywords

KiSS1 GPR54 Kisspeptin Cancer Metastasis 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Sung-Gook Cho
    • 1
  • Dali Li
    • 2
  • Kunrong Tan
    • 1
  • Stefan K. Siwko
    • 1
  • Mingyao Liu
    • 1
    • 2
  1. 1.Center for Cancer and Stem Cell Biology, Alkek Institute of Biosciences and TechnologyTexas A&M University Health Science CenterHoustonUSA
  2. 2.The Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiChina