Cancer and Metastasis Reviews

, Volume 30, Issue 3, pp 277–294

Cyclooxygenases and lipoxygenases in cancer

Article

DOI: 10.1007/s10555-011-9310-3

Cite this article as:
Schneider, C. & Pozzi, A. Cancer Metastasis Rev (2011) 30: 277. doi:10.1007/s10555-011-9310-3

Abstract

Cancer initiation and progression are multistep events that require cell proliferation, migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and ultimately secondary growth. Tumor cell functions at both primary or secondary sites are controlled by many different factors, including growth factors and their receptors, chemokines, nuclear receptors, cell–cell interactions, cell–matrix interactions, as well as oxygenated metabolites of arachidonic acid. The observation that cyclooxygenases and lipoxygenases and their arachidonic acid-derived eicosanoid products (prostanoids and HETEs) are expressed and produced by tumor cells, together with the finding that these enzymes can regulate cell growth, survival, migration, and invasion, has prompted investigators to analyze the roles of these enzymes in cancer progression. In this review, we focus on the contribution of cyclooxygenase- and lipoxygenase-derived eicosanoids to tumor cell function in vitro and in vivo and discuss hope and tribulations of targeting these enzymes for cancer prevention and treatment.

Keywords

CancerEicosanoidsThromboxaneProstacyclinProstaglandinsInhibitors

Abbreviations

COX

Cyclooxygenase

LOX

Lipoxygenase

PGE2

Prostaglandin E2

PGI2

Prostacyclin

PGF

Prostaglandin F

TxA2

Thromboxane A2

EP

Prostaglandin E receptor

HK

Cyclic hemiketal eicosanoid

NSAID

Nonsteroidal anti-inflammatory drug

LTB4

Leukotriene B4

HODE

Hydroxyoctadecadienoic acid

PGD2

Prostaglandin D2

VEGF

Vascular endothelial growth factor

NF-κB

Nuclear factor-kappaB

PI3K/Akt

Phospatidylinositol-3-kinase/Akt

PPAR

Peroxisome proliferator-activated receptor

TNF

Tumor necrosis factor

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of PharmacologyVanderbilt University Medical SchoolNashvilleUSA
  2. 2.Vanderbilt Institute of Chemical BiologyVanderbilt University Medical SchoolNashvilleUSA
  3. 3.Department of MedicineVanderbilt University Medical SchoolNashvilleUSA
  4. 4.Department of Cancer BiologyVanderbilt University Medical SchoolNashvilleUSA
  5. 5.Veterans Affairs HospitalsNashvilleUSA
  6. 6.Departments of Medicine and Cancer Biology, Division of Nephrology and HypertensionVanderbilt UniversityNashvilleUSA