Cancer and Metastasis Reviews

, Volume 30, Issue 2, pp 161–176

True local recurrences do not metastasize

NON-THEMATIC REVIEW

DOI: 10.1007/s10555-011-9275-2

Cite this article as:
Hölzel, D., Emeny, R.T. & Engel, J. Cancer Metastasis Rev (2011) 30: 161. doi:10.1007/s10555-011-9275-2

Abstract

Generally, the limits of local tumor control are in part connected with the term “field cancerization” and are known from oral, lung, prostate, or mammary cancer. With the example of breast cancer (BC), the problem of ipsilateral breast tumor recurrences (IBTR) after breast-conserving surgery will be reviewed. Three types of local recurrences are distinguished: true recurrences, new primaries, or residual tumors. Good data for BC allow the description of the time-dependent risk of these three types, relative to the diagnosis of the primary tumor, because the time of initiation and the growth duration of the IBTR can be estimated. Two hypotheses explain the data: first, local recurrences may be initiated years before the diagnosis of a primary tumor (PT) and can then appear as multifocal PT at diagnosis, and second, true local recurrences probably do not metastasize. The generalizability of these hypotheses for other tumors will be discussed.

Keywords

Breast cancerLocal recurrenceMultifocalMulticentric tumorMetastasization process

Abbreviations

BCS

breast-conserving surgery

IBTR

ipsilateral breast tumor recurrence

LR

local recurrence

MET

(distant) metastasization

NP

new primary

PT

primary (breast) tumor

RT

residual tumor

TC(D)

tumor cell (dissemination)

TR

true recurrence

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Dieter Hölzel
    • 1
  • Rebecca T. Emeny
    • 1
  • Jutta Engel
    • 1
    • 2
  1. 1.Munich Cancer Registry (MCR, Director J. Engel) of the Munich Cancer Center (MCC) at the Institute of medical InformaticsBiometry and Epidemiology (IBE), Ludwig-Maximilians-University (LMU) MunichMunichGermany
  2. 2.Tumorregister MünchenKlinikum GrosshadernMunichGermany