Cancer and Metastasis Reviews

, Volume 29, Issue 2, pp 243–248

Inflammation-mediated promotion of invasion and metastasis

Authors

  • Graziella Solinas
    • Laboratory for Immunology and InflammationIRCCS Istituto Clinico Humanitas
  • Federica Marchesi
    • Laboratory for Immunology and InflammationIRCCS Istituto Clinico Humanitas
  • Cecilia Garlanda
    • Laboratory for Immunology and InflammationIRCCS Istituto Clinico Humanitas
    • Laboratory for Immunology and InflammationIRCCS Istituto Clinico Humanitas
    • Dipartimento di Medicina TraslazionaleUniversity of Milan
  • Paola Allavena
    • Laboratory for Immunology and InflammationIRCCS Istituto Clinico Humanitas
Article

DOI: 10.1007/s10555-010-9227-2

Cite this article as:
Solinas, G., Marchesi, F., Garlanda, C. et al. Cancer Metastasis Rev (2010) 29: 243. doi:10.1007/s10555-010-9227-2

Abstract

Inflammation has been suggested to represent the seventh hallmark of cancer. Myelomonocytic cells are a key component of cancer-related inflammation. Tumor-associated macrophages and their mediators affect key elements in the multistep process of invasion and metastasis, from interaction with the extracellular matrix to the construction of a pre-metastatic niche. Evidence indicating that inflammatory mediators affect genetic stability and cause persistent epigenetic alterations suggests that inflammatory components of the tumor microenvironment impacts on fundamental mechanisms responsible for the generation of metastatic variants. These results provide impetus for efforts aimed at translating cancer-related inflammation into diagnostic–prognostic markers and innovative therapeutic strategies.

Keywords

CancerMyelomonocytic cellsMacrophagesMetastasisInvasion

Copyright information

© Springer Science+Business Media, LLC 2010