Cancer and Metastasis Reviews

, Volume 29, Issue 2, pp 339–350

Hereditary ovarian cancers: from BRCA mutations to clinical management. A modern appraisal


    • Department of Gynaecology and ObstetricsVito Fazzi Hospital
    • Department of Gynecology and Obstetric, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive TherapyVito Fazzi Hospital
  • Antonio Malvasi
    • Department of Gynaecology and ObstetricsSanta Maria Hospital
  • Giuseppe Leo
    • Molecular Biology and Experimental Oncology LabVito Fazzi Hospital
  • Daniele Vergara
    • Laboratory of Biology, Department of Biological and Environmental Sciences and Technologies (DiSTeBA)University of Salento
  • Maurizio Pisanò
    • Molecular Biology and Experimental Oncology LabVito Fazzi Hospital
  • Mariangela Ciccarese
    • Department of Clinical OncologyVito Fazzi Hospital
  • Vincenzo Emanuele Chiuri
    • Department of Clinical OncologyVito Fazzi Hospital
  • Vito Lorusso
    • Department of Clinical OncologyVito Fazzi Hospital

DOI: 10.1007/s10555-010-9218-3

Cite this article as:
Tinelli, A., Malvasi, A., Leo, G. et al. Cancer Metastasis Rev (2010) 29: 339. doi:10.1007/s10555-010-9218-3


In the past few years, ovarian cancer research has focused increasingly on disease prevention; but an increasing number of women refer to gynecology and clinical genetics clinics with a family history of ovarian cancer and inherited familial mutations. The interest on the issue has increased also due to the identification of BReast CAncer1 (BRCA1) and BRCA2 genes mutations. The importance of recognizing the characteristics of hereditary ovarian cancer (HOC) and manage women at risk appropriately will provide more accurate care of the high-risk population. Women at risk can be identified by pedigree analysis and may receive counseling from interdisciplinary cancer genetics clinics, while those at high risk need to receive genetic testing. Risk calculation programs define risks and assist in decision-making in clinical options and genetic testing; they provide information on the risks of the disease, mutation status, and the use of genetic testing in the management of high-risk families. Furthermore, while a large number of surrogate preliminary markers have been identified, there are still limited studies on ovarian cancer genomics. Different options for risk management of HOC are available: surveillance, chemoprevention and prophylactic surgery. Surveillance in HOC high-risk patients is still not accurate. Chemoprevention is currently a controversial topic, because a number of major issues still need to be addressed in developing and testing agents for ovarian cancer chemoprevention. Prophylactic surgery has been shown to effectively decrease cancer risk, and it has the possibility to substantially reduce ovarian cancer mortality.


Hereditary ovarian cancerBRCAProphylactic surgeryGeneticsGenetic testingHNPCCLaparoscopyOophorectomyCounselingRisk assessment

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© Springer Science+Business Media, LLC 2010