Cancer and Metastasis Reviews

, Volume 27, Issue 4, pp 715–735

Caveolin-1 in tumor progression: the good, the bad and the ugly

  • Jacky G. Goetz
  • Patrick Lajoie
  • Sam M. Wiseman
  • Ivan R. Nabi
NON-THEMATIC REVIEW

DOI: 10.1007/s10555-008-9160-9

Cite this article as:
Goetz, J.G., Lajoie, P., Wiseman, S.M. et al. Cancer Metastasis Rev (2008) 27: 715. doi:10.1007/s10555-008-9160-9

Abstract

Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding partners that is associated with cell surface caveolae and the regulation of lipid raft domains. Cav1 regulates multiple cancer-associated processes including cellular transformation, tumor growth, cell migration and metastasis, cell death and survival, multidrug resistance and angiogenesis. However, Cav1 has been reported to impact both positively and negatively on various aspects of tumor progression and while reported to function as a tumor suppressor, it has also been identified as a poor prognostic factor in various human cancers. In this review, we survey the functional roles of Cav1 in cancer and argue that Cav1 function is interdependent on tumor stage and the expression of molecular effectors that impact on its role during tumor progression.

Keywords

Caveolin-1CancerTumor progression

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jacky G. Goetz
    • 1
    • 3
  • Patrick Lajoie
    • 1
    • 4
  • Sam M. Wiseman
    • 2
  • Ivan R. Nabi
    • 1
  1. 1.Department of Cellular and Physiological Sciences, Life Sciences InstituteUniversity of British ColumbiaVancouverCanada
  2. 2.Department of SurgerySt. Paul’s Hospital and the University of British ColumbiaVancouverCanada
  3. 3.Integrin Signalling Laboratory, Department of Vascular Biology and InflammationCentro Nacional de Investigaciones Cardiovasculares (CNIC)MadridSpain
  4. 4.Department of Anatomy and Structural BiologyAlbert Einstein College of Medicine of Yeshiva UniversityBronxUSA