Cancer and Metastasis Reviews

, Volume 27, Issue 1, pp 67–73

Using metastasis suppressor proteins to dissect interactions among cancer cells and their microenvironment

  • Jennifer Taylor
  • Jonathan Hickson
  • Tamara Lotan
  • Diane Seiko Yamada
  • Carrie Rinker-Schaeffer
Article

DOI: 10.1007/s10555-007-9106-7

Cite this article as:
Taylor, J., Hickson, J., Lotan, T. et al. Cancer Metastasis Rev (2008) 27: 67. doi:10.1007/s10555-007-9106-7

Abstract

Cancer metastasis is a complex, dynamic process that begins with dissemination of cells from the primary tumor and culminates in the formation of clinically detectable, overt metastases at one or more discontinuous secondary sites. Evidence from in vivo video microscopy as well as PCR and immunohistochemical studies suggest that cancer cell dissemination is an early event in tumor progression and that cells may persist in a potentially dormant state for a prolonged period. Similarly, the mechanisms by which these disseminated cells initiate growth and complete the process of metastatic colonization remain largely unknown. Understanding signal transduction pathways regulating this final step of metastasis is therefore critical for successful clinical management. While genetic mutations or epigenetic changes may be required for a cell or group of cells to separate and survive distant from the primary tumor, the microenvironment within secondary tissues plays a substantial role in influencing whether disseminated cells survive and proliferate. Our work is focused on using metastasis suppressor proteins to gain insight into why the majority of disseminated cells, which should be fully malignant, do not proliferate immediately at secondary sites. The translational goal of this work is to identify targets for inhibiting metastatic growth and prolonging disease-free survival.

Keywords

Metastasis MKK4/JNKK1 SAPK Metastasis suppressor Dormancy 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Jennifer Taylor
    • 1
  • Jonathan Hickson
    • 2
    • 7
  • Tamara Lotan
    • 3
  • Diane Seiko Yamada
    • 2
  • Carrie Rinker-Schaeffer
    • 1
    • 2
    • 4
    • 5
    • 6
  1. 1.Committee on Cancer BiologyThe University of ChicagoChicagoUSA
  2. 2.Department of Obstetrics and GynecologyThe University of ChicagoChicagoUSA
  3. 3.Department of PathologyThe University of ChicagoChicagoUSA
  4. 4.Section of Urology, Department of SurgeryThe University of ChicagoChicagoUSA
  5. 5.The University of Chicago Interdepartmental Metastasis Research Group (UCIMRG)ChicagoUSA
  6. 6.University of Chicago Cancer Research CenterThe University of ChicagoChicagoUSA
  7. 7.Dept. R4N2Abbott LaboratoriesAbbott ParkUSA