Cancer and Metastasis Reviews

, Volume 26, Issue 3, pp 579–585

Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer

Authors

    • Program in Molecular Biology and Genetics, Department of Pathology, Karmanos Cancer InstituteWayne State University School of Medicine
Article

DOI: 10.1007/s10555-007-9079-6

Cite this article as:
Wu, G.S. Cancer Metastasis Rev (2007) 26: 579. doi:10.1007/s10555-007-9079-6

Abstract

The mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are a family of dual-specificity protein phosphatases that dephosphorylate both phospho-threonine and phospho-tyrosine residues in MAP kinases, including the c-Jun N-terminal protein kinase (JNK)/stress-activated protein kinase (SAPK), the p38 MAPK, and the extracellular signal-related kinase (ERK). Since phosphorylation is required for the activation of MAP kinases, dephosphorylation by MKPs inhibits MAPK activity, thereby negatively regulating MAPK signaling. It is known that deregulation of MAPK signaling is the most common alteration in human cancers. Recent studies have suggested that MKPs play an important role not only in the development of cancers, but also in the response of cancer cells to chemotherapy. Thus, understanding the roles of MKPs in the development of cancer and their impact on chemotherapy can be exploited for therapeutic benefits for the treatment of human cancer.

Keywords

CancerMKPMAPKs

Copyright information

© Springer Science+Business Media, LLC 2007