Cancer and Metastasis Reviews

, Volume 26, Issue 3, pp 401–420

Chemokines: novel targets for breast cancer metastasis

Authors

  • Simi Ali
    • School of Surgical and Reproductive Sciences, Medical SchoolUniversity of Newcastle upon Tyne
    • INSERM
    • University of Montpellier I
Article

DOI: 10.1007/s10555-007-9073-z

Cite this article as:
Ali, S. & Lazennec, G. Cancer Metastasis Rev (2007) 26: 401. doi:10.1007/s10555-007-9073-z

Abstract

Recent studies have highlighted the possible involvement of chemokines and their receptors in breast cancer progression and metastasis. Chemokines and their receptors constitute a superfamily of signalling factors whose prognosis value in breast cancer progression remains unclear. We will examine here the expression pattern of chemokines and their receptors in mammary gland physiology and carcinogenesis. The nature of the cells producing chemokines or harboring chemokine receptors appears to be crucial in certain conditions for example, the infiltration of the primary tumor by leukocytes and angiogenesis. In addition, chemokines, their receptors and the interaction with glycosaminoglycan (GAGs) are key players in the homing of cancer cells to distant metastasis sites. Several lines of evidence, including in vitro and in vivo models, suggest that the mechanism of action of chemokines in cancer development involves the modulation of proliferation, apoptosis, invasion, leukocyte recruitment or angiogenesis. Furthermore, we will discuss the regulation of chemokine network in tumor neovascularity by decoy receptors. The reasons accounting for the deregulation of chemokines and chemokine receptors expression in breast cancer are certainly crucial for the comprehension of chemokine role in breast cancer and are in several cases linked to estrogen receptor status. The targeting of chemokines and chemokine receptors by antibodies, small molecule antagonists, viral chemokine binding proteins and heparins appears as promising tracks to develop therapeutic strategies. Thus there is significant interest in developing strategies to antagonize the chemokine function, and an opportunity to interfere with metastasis, the leading cause of death in most patients.

Keywords

Chemokines Breast cancer Metastasis Glycosaminoglycan Tumor associated macrophages Estrogen receptor

Copyright information

© Springer Science+Business Media, LLC 2007