Cancer and Metastasis Reviews

, Volume 24, Issue 3, pp 383–393

Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression


DOI: 10.1007/s10555-005-5130-7

Cite this article as:
Walker, J.L. & Assoian, R.K. Cancer Metastasis Rev (2005) 24: 383. doi:10.1007/s10555-005-5130-7


Integrins and growth factor receptors coordinately regulate proliferation in nontransformed cells. Coordinate signaling from these receptors controls the activation of the G1 phase cyclin-dependent kinases, largely by regulating levels of cyclin D1 and p27kip1. Induction of cyclin D1 is one of the best understood examples of an integrin/growth factor receptor-regulated G1 phase target. This review focuses on the integrin-dependent signal transduction events that regulate the expression of cyclin D1 during G1 phase.


adhesion signaling cell cycle growth factor receptor 

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphia

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