Cancer and Metastasis Reviews

, Volume 24, Issue 2, pp 237–250

A Wnt-er Wonderland—The complexity of Wnt signaling in melanoma


DOI: 10.1007/s10555-005-1574-z

Cite this article as:
Weeraratna, A.T. Cancer Metastasis Rev (2005) 24: 237. doi:10.1007/s10555-005-1574-z


Wnt signaling is a complex process that requires the interplay of several different proteins. In addition to a large cohort of Wnt ligands, and frizzled receptors, some Wnt pathways also require the presence of co-receptors. Wnt ligands may activate one of three pathways, the canonical pathway, involving β -catenin, the planar cell polarity pathway and the Wnt/ calcium pathway. All three pathways have different results for the cells in which they signal. Aberrant activation of these pathways can lead to the development and progression of several cancers. In this review we will discuss the different Wnt pathways, and their contribution to melanoma progression.

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© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Laboratory of Immunology, The National Institute on AgingNational Institutes of HealthBaltimore