MRI comparison of quantitative left ventricular structure, function and measurement reproducibility in patient cohorts with a range of clinically distinct cardiac conditions

  • Stephen J. Gandy
  • Shelley A. Waugh
  • R. Stephen Nicholas
  • Narasimharaj Rajendra
  • Patricia Martin
  • J. Graeme Houston
Original Paper

DOI: 10.1007/s10554-008-9293-5

Cite this article as:
Gandy, S.J., Waugh, S.A., Nicholas, R.S. et al. Int J Cardiovasc Imaging (2008) 24: 627. doi:10.1007/s10554-008-9293-5

Abstract

Aim Quantitative MRI assessments of cardiac structure and function are possible and potentially useful for longitudinal clinical monitoring. The aim of this study was to compare the magnitude and repeatability of left ventricular (LV) ejection fraction (EF) and mass (LVM) measurements in patients with clinically distinct cardiac conditions. Materials and Methods Patients were recruited into four groups: (i) congestive heart failure (CHF), (ii) left ventricular hypertrophy (LVH), (iii) recent post myocardial infarct (PMI), and (iv) healthy normal volunteers (HNV). LV short-axis images were acquired on a 1.5T MRI scanner and analysed on a satellite workstation. EF and LVM (at ED) values were derived from myocardial segmentations, and intra-observer test-retest coefficients of repeatability (CoR) were determined for each cohort. Results The mean EF for the CHF patients (30.3%) was lower than for the other cohorts (LVH 72.7%, PMI 53.0%, HNV 67.0%; P < 0.0002). As expected, the mean LVM for the CHF patients (143 g) was greater than for the other cohorts (LVH 122 g, PMI 124 g, HNV 107 g), but only significant when compared to the HNV cohort (P = 0.004). The intra-observer CoR values for EF were 1.5% (LVH), 1.6% (HNV), 2.6% (PMI) and 5.5% (CHF), and 4.6 g (HNV), 6.7 g (PMI), 8.3 g (CHF) and 9.8 g (LVH) for LVM. Conclusion The EF, LVM and associated repeatability parameters are variable and dependent upon the clinical condition under investigation. It is important that reproducibility data for EF and LVM are acquired individually and specifically on a per-cohort basis if the parameters are to form reliable endpoints for longitudinal clinical follow-up assessments.

Keywords

Magnetic resonance imagingLeft ventricular ejection fractionLeft ventricular massRepeatabilityPatient volunteers

Abbreviations

CHF

Congestive heart failure

CoR

Coefficient of repeatability

CoV

Coefficient of variation

ED

End diastole

EF

Ejection fraction

ES

End systole

HNV

Healthy normal volunteers

LV

Left ventricle

LVH

Left ventricular hypertrophy

LVM (ED)

Left ventricular mass at end diastole

MRI

MRI

PMI

Post myocardial infarct

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Stephen J. Gandy
    • 1
    • 2
  • Shelley A. Waugh
    • 1
    • 2
  • R. Stephen Nicholas
    • 1
    • 2
  • Narasimharaj Rajendra
    • 3
  • Patricia Martin
    • 2
  • J. Graeme Houston
    • 2
  1. 1.Department of Medical Physics NHS Tayside, Ninewells HospitalDundeeUK
  2. 2.Department of Clinical RadiologyNHS Tayside, Ninewells HospitalDundeeUK
  3. 3.University of Dundee School of Medicine, Ninewells HospitalDundeeUK