Date: 10 Jan 2008

Lesion characteristics and subsequent atherosclerotic disease progression. Insights into the dynamic process of coronary atherosclerosis

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access
This is an excerpt from the content

The goal of coronary imaging with conventional coronary angiography is the identification of focal culprit lesions causing acute or chronic symptoms. Subsequent treatment decisions are based on this static observation of symptomatic, advanced stages of coronary artery disease (CAD). However, coronary atherosclerosis begins much earlier and is a highly dynamic, systemic process with gradual plaque build-up and intermittent superimposed sudden changes causing asymptomatic accelerated progression or symptomatic, focal complications [1].

An attractive diagnostic approach would be the identification of lesion characteristics associated with future progression before events occur. This approach is described with the concept of the “vulnerable plaque/vulnerable patient”. Treatment decisions based on such knowledge, reflecting the dynamic atherosclerotic disease process, would allow early initiation of risk factor modification and presumably prevention of coronary events.

Current knowledge of vu ...