The International Journal of Cardiovascular Imaging

, Volume 21, Issue 4, pp 425-441

Rationale and methods of the integrated biomarker and imaging study (IBIS): combining invasive and non-invasive imaging with biomarkers to detect subclinical atherosclerosis and assess coronary lesion biology

  • Carlos A. G. Van. MieghemAffiliated withErasmus Medical Center
  • , Nico BruiningAffiliated withErasmus Medical Center
  • , Johannes A. SchaarAffiliated withInteruniversity Cardiology Institute of the Netherlands
  • , Eugene McFaddenAffiliated withErasmus Medical Center
  • , Nico MolletAffiliated withErasmus Medical Center
  • , Filippo CademartiriAffiliated withErasmus Medical Center
  • , Frits MastikAffiliated withInteruniversity Cardiology Institute of the Netherlands
  • , Jurgen M. R. LigthartAffiliated withErasmus Medical Center
  • , Gaston A. Rodriguez. GranilloAffiliated withErasmus Medical Center
    • , Marco ValgimigliAffiliated withErasmus Medical Center
    • , Georgios SianosAffiliated withErasmus Medical Center
    • , Willem J. van der. GiessenAffiliated withErasmus Medical Center
    • , Bianca BackxAffiliated withCardialysis
    • , Marie-Angele M. MorelAffiliated withCardialysis
    • , Gerrit-Anne Van EsAffiliated withCardialysis
    • , Jonathon D. SawyerAffiliated withGlaxoSmithKline
    • , June KaplowAffiliated withGlaxoSmithKline
    • , Andrew ZalewskiAffiliated withGlaxoSmithKline
    • , Anton F. W. vander. SteenAffiliated withInteruniversity Cardiology Institute of the Netherlands
    • , Pim de FeyterAffiliated withErasmus Medical Center
    • , Patrick W. SerruysAffiliated withErasmus Medical Center Email author 

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Death or myocardial infarction, the most serious clinical consequences of atherosclerosis, often result from plaque rupture at non-flow limiting lesions. Current diagnostic imaging with coronary angiography only detects large plaques that already impinge on the lumen and cannot accurately identify those that have a propensity to cause unheralded events. Accurate evaluation of the composition or of the biomechanical characteristics of plaques with invasive or non-invasive methods, alone or in conjunction with assessment of circulating biomarkers, could help identify high-risk patients, thus providing the rationale for aggressive treatments in order to reduce future clinical events. The IBIS (Integrated Biomarker and Imaging Study) study is a prospective, single-center, non-randomized, observational study conducted in Rotterdam. The aim of the IBIS study is to evaluate both invasive (quantitative coronary angiography, intravascular ultrasound (IVUS) and palpography) and non-invasive (multislice spiral computed tomography) imaging techniques to characterize non-flow limiting coronary lesions. In addition, multiple classical and novel biomarkers will be measured and their levels correlated with the results of the different imaging techniques. A minimum of 85 patients up to a maximum of 120 patients will be included. This paper describes the study protocol and methodological solutions that have been devised for the purpose of comparisons among several imaging modalities. It outlines the analyses that will be performed to compare invasive and non-invasive imaging techniques in conjunction with multiple biomarkers to characterize non-flow limiting subclinical coronary lesions.


atherosclerosis biomarkers computed tomography coronary artery disease intravascular ultrasound palpography