Cancer Causes & Control

, Volume 25, Issue 10, pp 1329–1336

Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history

  • Sophie Morois
  • Vanessa Cottet
  • Antoine Racine
  • Françoise Clavel-Chapelon
  • Franck Carbonnel
  • Nadia Bastide
  • Marie-Christine Boutron-Ruault
Original paper

DOI: 10.1007/s10552-014-0438-7

Cite this article as:
Morois, S., Cottet, V., Racine, A. et al. Cancer Causes Control (2014) 25: 1329. doi:10.1007/s10552-014-0438-7

Abstract

Purpose

Colonoscopy efficacy at preventing proximal colorectal cancer (CRC) is questioned, and little is known about efficacy in high-risk versus medium-risk populations. We investigated the relationship between colonoscopy screening, family history of colorectal cancer (FHCC), and CRC risk by site.

Methods

Among 92,078 women of the E3N prospective cohort, 692 CRCs have been diagnosed after a median follow-up of 15.4 years. Cox proportional hazard models estimated adjusted hazards ratios according to subsites of cancer and FHCC.

Results

A personal history of colonoscopy (PHC; n = 37,470) was associated with decreased rectal and distal colon cancer risks (hazard ratio (HR) = 0.57; 95 % Confidence Interval (CI) = 0.42–0.78 and HR = 0.37; 95 % CI = 0.26–0.52, respectively), but not proximal colon cancer risk (HR = 0.87; 95 % CI = 0.64–1.18). In women with no prior colonoscopy, those with FHCC had a 80 % higher CRC risk than those without FHCC. In women with previous colonoscopy, CRC risk was similar in women with and without FHCC (p for interaction = 0.04).

Conclusions

Results showed colonoscopy ability to prevent distal cancers, but not proximal cancers in women. Colonoscopy screening also reduced the excess risk of women with FHCC to that of women with no FHCC.

Keywords

Colorectal cancerColonoscopyFamily historyProspective studyScreeningEfficacy

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Sophie Morois
    • 1
    • 2
  • Vanessa Cottet
    • 3
    • 4
    • 5
  • Antoine Racine
    • 1
    • 2
  • Françoise Clavel-Chapelon
    • 1
    • 2
  • Franck Carbonnel
    • 1
    • 2
    • 6
  • Nadia Bastide
    • 1
    • 2
  • Marie-Christine Boutron-Ruault
    • 1
    • 2
  1. 1.INSERM U1018, Team 9Institut Gustave Roussy, Espace Maurice TubianaVillejuif CedexFrance
  2. 2.UMRS 1018Université Paris Sud 11Villejuif CedexFrance
  3. 3.Registre Bourguignon des Cancers DigestifsUniversité de BourgogneDijonFrance
  4. 4.INSERM U866Université de BourgogneDijonFrance
  5. 5.CHU DIJONUniversité de BourgogneDijonFrance
  6. 6.Service d’HépatogastroentérologieCentre Hospitalier de BicêtreLe Kremlin BicêtreFrance