, Volume 25, Issue 9, pp 1197-1209
Date: 03 Jul 2014

Ethnic and geographic variations in corpus uteri cancer burden: evidence based on data from 29 states and the District of Columbia. CI5 IX, X and SEER data (1998–2010)

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Abstract

Purpose

To assess the pattern of corpus uteri cancer (CUC) in individual states of the USA according to ethnicity.

Methods

Population-based cancer registries from 29 states and the District of Columbia with information on ethnicity for African-American women (AA) and Caucasian-American women (CA) were extracted from the Cancer Incidence in Five Continents (1998–2002, 2003–2007) and the Surveillance, Epidemiology, and End Results Program (SEER; 2008–2010) databases. Rate ratios (RRs) were calculated with respect to ethnicity, age, state, and region.

Results

In southern states, AA had a lower CUC burden among women aged <60 years (AA/CA RR = 0.67; 95 % CI 0.64–0.70), whereas it was higher among women aged ≥60 years (AA/CA RR = 1.22; 95 % CI 1.19–1.26). In other regions, the lower CUC burden among AA aged <60 years was true in all states; however, the CUC burden among AA aged ≥60 years was similar to that of CA. Data for the most recent period (2008–2010) indicate that the age-dependent crossover in CUC burden was not anymore restricted to the South, but also occurred in other regions. Overall, women in the South have had the lowest CUC burden compared with that in all other regions, irrespective of ethnicity and age.

Conclusions

Significant geographic and ethnic variations in the CUC burden exist in the USA. The incidence of hysterectomy could be a factor underlying the geographic variations in CUC burden and particular attention should be given to older AA in southern states.