Cancer Causes & Control

, Volume 25, Issue 4, pp 515–523

Physical activity and prostate gene expression in men with low-risk prostate cancer

  • Mark Jesus M. Magbanua
  • Erin L. Richman
  • Eduardo V. Sosa
  • Lee W. Jones
  • Jeff Simko
  • Katsuto Shinohara
  • Christopher M. Haqq
  • Peter R. Carroll
  • June M. Chan
Original Paper

DOI: 10.1007/s10552-014-0354-x

Cite this article as:
Magbanua, M.J.M., Richman, E.L., Sosa, E.V. et al. Cancer Causes Control (2014) 25: 515. doi:10.1007/s10552-014-0354-x

Abstract

Purpose

Vigorous physical activity after diagnosis of localized prostate cancer may reduce the risk of disease progression and prostate cancer-specific mortality. The molecular mechanisms by which physical activity may exert protective effects in the prostate remain unknown.

Methods

We examined the associations between self-reported physical activity and gene expression patterns in morphologically normal prostate tissue of 71 men with low-risk prostate cancer on active surveillance. Differential gene expression, gene set, and pathway analyses were conducted comparing dichotomous groups defined by type, intensity, and amount of physical activity reported.

Results

Cell cycling and DNA repair pathways were up-regulated in men who participated in ≥ 3 h/week vigorous activity compared with men who did not. In addition, canonical pathways involved in cell signaling and metabolism, the cellular effects of sildenafil (Viagra), and the Nrf2-mediated oxidative stress response were modulated in men who reported ≥ 3 h/week of vigorous activity. Differential expression analysis at the individual gene level revealed modest differences between men who performed vigorous activity for ≥ 3 h/week and those who did not. There were no differences in prostate gene expression in comparisons with exercise groupings that did not consider both duration and intensity of activity.

Conclusions

Prostate gene expression and pathway analyses revealed sets of transcripts that may be modulated in normal prostate tissue by participating in ≥ 3 h/week of vigorous activity after diagnosis of low-risk prostate cancer. These findings suggest potential biological mechanisms by which vigorous activity may reduce risk of prostate cancer progression and warrant further study and validation.

Keywords

Physical activity Exercise Gene expression Prostate cancer 

Supplementary material

10552_2014_354_MOESM1_ESM.docx (24 kb)
Supplementary material 1 (DOCX 23 kb)
10552_2014_354_MOESM2_ESM.docx (118 kb)
Supplementary material 2 (DOCX 117 kb)
10552_2014_354_MOESM3_ESM.docx (25 kb)
Supplementary material 3 (DOCX 25 kb)
10552_2014_354_MOESM4_ESM.xlsx (19 kb)
Supplementary material 4 (XLSX 18 kb)
10552_2014_354_MOESM5_ESM.xlsx (12 kb)
Supplementary material 5 (XLSX 11 kb)
10552_2014_354_MOESM6_ESM.xlsx (13 kb)
Supplementary material 6 (XLSX 12 kb)
10552_2014_354_MOESM7_ESM.docx (24 kb)
Supplementary material 7 (DOCX 23 kb)
10552_2014_354_MOESM8_ESM.docx (15 kb)
Supplementary material 8 (DOCX 15 kb)
10552_2014_354_MOESM9_ESM.docx (382 kb)
Supplementary material 9 (DOCX 382 kb)
10552_2014_354_MOESM10_ESM.docx (62 kb)
Supplementary material 10 (DOCX 62 kb)

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Mark Jesus M. Magbanua
    • 1
  • Erin L. Richman
    • 2
  • Eduardo V. Sosa
    • 3
  • Lee W. Jones
    • 4
  • Jeff Simko
    • 3
    • 5
    • 7
  • Katsuto Shinohara
    • 3
  • Christopher M. Haqq
    • 3
  • Peter R. Carroll
    • 3
    • 6
  • June M. Chan
    • 2
    • 3
    • 6
  1. 1.Division of Hematology/OncologyUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Department of Epidemiology and BiostatisticsUniversity of California San FranciscoSan FranciscoUSA
  3. 3.Department of UrologyUniversity of California San FranciscoSan FranciscoUSA
  4. 4.Duke Cancer InstituteDuke University Medical CenterDurhamUSA
  5. 5.Department of PathologyUniversity of California San FranciscoSan FranciscoUSA
  6. 6.Helen Diller Family Comprehensive Cancer CenterUniversity of California San FranciscoSan FranciscoUSA
  7. 7.Department of Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA