Cancer Causes & Control

, Volume 24, Issue 8, pp 1575–1581

Coffee and risk of prostate cancer incidence and mortality in the Cancer of the Prostate in Sweden Study

  • Kathryn M. Wilson
  • Katarina Bälter
  • Elisabeth Möller
  • Hans-Olov Adami
  • Ove Andrén
  • Swen-Olof Andersson
  • Henrik Grönberg
  • Lorelei A. Mucci
Original paper

DOI: 10.1007/s10552-013-0234-9

Cite this article as:
Wilson, K.M., Bälter, K., Möller, E. et al. Cancer Causes Control (2013) 24: 1575. doi:10.1007/s10552-013-0234-9

Abstract

Purpose

Coffee intake has recently been associated with significantly lower risk of lethal and advanced prostate cancer in a US population.

Methods

We studied the association between coffee and prostate cancer risk in the population-based case–control study Cancer of the Prostate in Sweden. Dietary data were available for 1,499 cases and 1,112 controls. We calculated odds ratios (ORs) for the risk of prostate cancer in high versus low categories of coffee intake using logistic regression. We studied overall prostate cancer risk as well as risk of fatal, advanced, localized, high-grade, grade 7, and low-grade disease.

Results

Mean coffee intake was 3.1 cups per day among both cases and controls. Coffee intake was not associated with overall prostate cancer risk. Risk of fatal prostate cancer was inversely, but not statistically significantly, associated with coffee intake, with an odds ratio of 0.64 [95 % confidence interval (CI) 0.34–1.19, p value for linear trend = 0.81] for men consuming greater than 5 cups per day compared to men drinking less than 1 cup per day. The highest intake of coffee was associated non-significantly with lower risk of advanced disease (OR = 0.73, 95 % CI 0.41–1.30, p trend = 0.98) and associated significantly with lower risk of high-grade cancer (Gleason 8–10; OR = 0.50, 95 % CI 0.26–0.98, p trend = 0.13). Risk of localized, grade 7, and low-grade cancers was not associated with coffee intake.

Conclusions

This study provides some support of an inverse association between coffee and lethal and high-grade prostate cancer.

Keywords

Coffee Diet Prostate cancer 

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Kathryn M. Wilson
    • 1
    • 2
  • Katarina Bälter
    • 3
  • Elisabeth Möller
    • 3
  • Hans-Olov Adami
    • 1
    • 3
  • Ove Andrén
    • 4
  • Swen-Olof Andersson
    • 4
  • Henrik Grönberg
    • 3
  • Lorelei A. Mucci
    • 1
    • 2
  1. 1.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  2. 2.Channing Division of Network MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden
  4. 4.Örebro University HospitalÖrebroSweden