Cancer Causes & Control

, Volume 24, Issue 5, pp 1033–1044

Anthropometric factors, physical activity, and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women: a case–control study

Authors

  • Masaaki Kawai
    • Division of Community HealthTohoku University Graduate School of Medicine
    • Department of Surgical OncologyTohoku University Graduate School of Medicine
  • Yoichiro Kakugawa
    • Department of Breast OncologyMiyagi Cancer Center Hospital
  • Yoshikazu Nishino
    • Division of Cancer Epidemiology and PreventionMiyagi Cancer Center Research Institute
  • Yohei Hamanaka
    • Department of Breast OncologyMiyagi Cancer Center Hospital
    • Department of Surgical OncologyTohoku University Graduate School of Medicine
  • Noriaki Ohuchi
    • Department of Surgical OncologyTohoku University Graduate School of Medicine
    • Division of Community HealthTohoku University Graduate School of Medicine
    • Division of Cancer Epidemiology and PreventionMiyagi Cancer Center Research Institute
Original paper

DOI: 10.1007/s10552-013-0181-5

Cite this article as:
Kawai, M., Kakugawa, Y., Nishino, Y. et al. Cancer Causes Control (2013) 24: 1033. doi:10.1007/s10552-013-0181-5

Abstract

Purpose

The associations between anthropometric factors, physical activity (PA), and breast cancer risk in terms of estrogen-receptor/progesterone-receptor (ER/PgR) status have been unclear in Japanese women. This case–control study was designed to evaluate these associations.

Methods

From among female patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2009, 1,017 breast cancer cases (538ER+/PgR+, 125ER+/PgR−, 23 ER−/PgR+, 249 ER−/PgR−, and 82 missing) and 2,902 controls were selected. Height, weight, body mass index (BMI) (kg/m2), and time spent exercising (hours/week) were assessed using a self-administered questionnaire. Polytomous logistic regression analysis and tests for heterogeneity across ER+/PgR+ and ER−/PgR− were conducted.

Results

Higher BMI was associated with a higher risk of ER+/PgR+ cancer among women overall [odds ratio (OR) = 2.41, 95 % confidence interval (CI) 1.37–4.23 for BMI ≥30.0; Ptrend = 0.0001] and postmenopausal women (OR = 6.24, 95 % CI 2.68–14.53 for BMI ≥30.0; Ptrend < 0.0001). A longer time spent exercising (more than 5 h/week) showed a decreased risk for any type of breast cancer among overall and pre- and postmenopausal women, although this did not reach statistical significance. Height was not associated with any risk.

Conclusions

Higher BMI is associated with an increased risk of ER+/PgR+ cancer among women overall and postmenopausal women. PA might be associated with a decreased risk of any type. To prevent breast cancer, weight control and PA are important.

Keywords

Breast cancerAnthropometric factorsPhysical activityHormone receptorMenopausal statusCase–control study

Copyright information

© Springer Science+Business Media Dordrecht 2013