Cancer Causes & Control

, Volume 24, Issue 4, pp 783–793

Childhood acute leukemia, maternal beverage intake during pregnancy, and metabolic polymorphisms

Authors

  • Audrey Bonaventure
    • Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018Environmental epidemiology of Cancer Group
    • Univ Paris-Sud, UMRS 1018
    • Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018Environmental epidemiology of Cancer Group
    • Univ Paris-Sud, UMRS 1018
    • RNHE, National Registry of Childhood Hematopoietic Malignancies
  • Stéphanie Goujon-Bellec
    • Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018Environmental epidemiology of Cancer Group
    • Univ Paris-Sud, UMRS 1018
    • RNHE, National Registry of Childhood Hematopoietic Malignancies
  • Laurent Orsi
    • Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018Environmental epidemiology of Cancer Group
    • Univ Paris-Sud, UMRS 1018
  • Guy Leverger
    • AP-HP, Hôpital Armand Trousseau
    • Université Paris 6 Pierre et Marie Curie
  • André Baruchel
    • AP-HP, Hôpital Robert Debré
    • Université Paris 7
  • Yves Bertrand
    • Institut d’Hémato-Oncologie Pédiatrique
  • Brigitte Nelken
    • Hôpital Jeanne de Flandre, CHRU
    • Université Lille Nord de France
  • Marlène Pasquet
    • Hôpital des Enfants
  • Gérard Michel
    • AP-HM, Hôpital la Timone
  • Nicolas Sirvent
    • Hôpital Arnaud de Villeneuve
  • Pierre Bordigoni
    • CHU de Nancy
  • Stéphane Ducassou
    • Hematology and Oncology, Children’s Hospital, PellegrinBordeaux University Hospital
  • Xavier Rialland
    • Hôpital Mère-Enfant, CHU-Nantes
    • CHU d’Angers
  • Diana Zelenika
    • Commissariat à l’Energie Atomique (CEA) Genomics Institute-Centre National de Génotypage
  • Denis Hémon
    • Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018Environmental epidemiology of Cancer Group
    • Univ Paris-Sud, UMRS 1018
  • Jacqueline Clavel
    • Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018Environmental epidemiology of Cancer Group
    • Univ Paris-Sud, UMRS 1018
    • RNHE, National Registry of Childhood Hematopoietic Malignancies
Original paper

DOI: 10.1007/s10552-013-0161-9

Cite this article as:
Bonaventure, A., Rudant, J., Goujon-Bellec, S. et al. Cancer Causes Control (2013) 24: 783. doi:10.1007/s10552-013-0161-9

Abstract

Purpose

This study aimed to analyze the associations between childhood acute leukemia (AL) and maternal caffeinated beverage consumption during pregnancy, and to explore interactions between caffeinated and alcoholic beverage consumption and polymorphisms of enzymes involved in caffeine and ethanol metabolisms.

Methods

The data were generated by the French ESCALE study, which included 764 AL cases and 1,681 controls in 2003–2004. The case and control mothers were interviewed on their consumption habits during pregnancy using a standardized questionnaire. Genotypes of the candidate alleles (NAT2*5 rs1801280, ADH1C*2 rs698 and rs1693482, CYP2E1*5 rs2031920 and rs3813867) were obtained using high-throughput genotyping and imputation data for 493 AL cases and 549 controls with at least two grandparents born in Europe.

Results

Maternal regular coffee consumption during pregnancy was associated with childhood AL (OR = 1.2 [1.0–1.5], p = 0.02); the odds ratios increased linearly with daily intake (p for trend <0.001; >2 cups per day vs. no or less than 1 cup per week: AL: OR = 1.6 [1.2–2.1], lymphoblastic AL: OR = 1.5 [1.1–2.0], myeloblastic AL: OR = 2.4 [1.3–4.3]). The association was slightly more marked for children born to non-smoking mothers. Lymphoblastic AL was also associated with cola soda drinking (OR = 1.3 [1.0–1.5], p = 0.02). No significant gene–environment interactions with coffee, tea, cola soda, or alcohol drinking were observed.

Conclusion

This study provides additional evidence that maternal coffee consumption during pregnancy may be associated with childhood AL. Coffee consumption is a prevalent habit and its potential involvement in childhood AL needs to be considered further.

Keywords

Childhood leukemiaCoffeeAlcoholPregnancyGeneInteraction

Abbreviations

AL

Acute leukemia

ALL

Acute lymphoblastic leukemia

AML

Acute myeloblastic leukemia

CEU

Utah residents with Northern and Western European ancestry from the CEPH collection

CEPH

Centre d’Etude du Polymorphisme Humain

CYP2E1

Cytochrome P450 2E1

NAT2

N-acetyltransferase 2

ADH

Alcohol dehydrogenase

Copyright information

© Springer Science+Business Media Dordrecht 2013