Cancer Causes & Control

, Volume 24, Issue 4, pp 749–757

Agreement for tumor grade of ovarian carcinoma: analysis of archival tissues from the surveillance, epidemiology, and end results residual tissue repository

  • Rayna K. Matsuno
  • Mark E. Sherman
  • Kala Visvanathan
  • Marc T. Goodman
  • Brenda Y. Hernandez
  • Charles F. Lynch
  • Olga B. Ioffe
  • David Horio
  • Charles Platz
  • Sean F. Altekruse
  • Ruth M. Pfeiffer
  • William F. Anderson
Original paper

DOI: 10.1007/s10552-013-0157-5

Cite this article as:
Matsuno, R.K., Sherman, M.E., Visvanathan, K. et al. Cancer Causes Control (2013) 24: 749. doi:10.1007/s10552-013-0157-5

Abstract

Background

Emerging data suggest that ovarian cancers differ by tumor grade. However, the reliability of microscopic grade from paraffin tissue in the general medical community and as reflected in population-based cancer registries is unknown.

Methods

We examined grade agreement between two gynecologic pathologists and the Surveillance Epidemiology and End Results Residual Tissue Repository (SEER). Grade agreement was assessed with percent observer agreement and kappa coefficients for 664 invasive ovarian carcinomas, using previously defined three-tier and two-tier grading systems. A random subset of ovarian carcinomas was selected to compare intra- and inter-pathologist agreement.

Results

Five hundred and eighty-six of SEER’s 664 tumors were confirmed invasive. Percent agreement was 49 % with fair kappa coefficient = 0.25 (95 % CI: 0.20–0.30) for the 664 tumors. Agreement improved slightly when restricted to the 586 confirmed invasive cancers; it was better for high grade than low grade tumors, for two-tier than three-tier grading systems, and within (66 %) than between study pathologists (43 %). Grade was not a robust independent predictor of ovarian cancer-specific survival.

Conclusions

Grade agreement was fair between SEER and study pathologists irrespective of grading system. Recorded grade in SEER should be used with caution and is probably not a reliable metric for ovarian cancer epidemiology.

Keywords

EpidemiologyOvarian cancerTumor gradeSEERKappa coefficient

Supplementary material

10552_2013_157_MOESM1_ESM.docx (42 kb)
Supplementary material 1 (DOCX 42 kb)

Copyright information

© Springer Science+Business Media Dordrecht (outside the USA) 2013

Authors and Affiliations

  • Rayna K. Matsuno
    • 1
    • 2
    • 3
  • Mark E. Sherman
    • 1
  • Kala Visvanathan
    • 3
  • Marc T. Goodman
    • 2
  • Brenda Y. Hernandez
    • 2
  • Charles F. Lynch
    • 4
  • Olga B. Ioffe
    • 5
  • David Horio
    • 2
  • Charles Platz
    • 6
  • Sean F. Altekruse
    • 7
  • Ruth M. Pfeiffer
    • 1
  • William F. Anderson
    • 1
  1. 1.DHHS/NIH/National Cancer Institute/Division of Cancer Epidemiology and GeneticsRockvilleUSA
  2. 2.Epidemiology DepartmentUniversity of Hawaii Cancer CenterHonoluluUSA
  3. 3.Department of EpidemiologyJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA
  4. 4.Department of EpidemiologyThe University of IowaIowa CityUSA
  5. 5.Department of PathologyUniversity of Maryland School of MedicineBaltimoreUSA
  6. 6.Department of PathologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA
  7. 7.DHHS/NIH/National Cancer Institute/Division of Cancer Control and Population SciencesRockvilleUSA