Cancer Causes & Control

, Volume 23, Issue 4, pp 521–535

Carbohydrates, glycemic index, glycemic load, and colorectal cancer risk: a systematic review and meta-analysis of cohort studies

  • D. Aune
  • D. S. M. Chan
  • R. Lau
  • R. Vieira
  • D. C. Greenwood
  • E. Kampman
  • T. Norat
Review article

DOI: 10.1007/s10552-012-9918-9

Cite this article as:
Aune, D., Chan, D.S.M., Lau, R. et al. Cancer Causes Control (2012) 23: 521. doi:10.1007/s10552-012-9918-9

Abstract

Background

Dietary carbohydrate, glycemic index, and glycemic load are thought to influence colorectal cancer risk through hyperinsulinemia. We review and quantitatively summarize in a meta-analysis the evidence from prospective cohort studies.

Methods

We searched the PubMed database for prospective studies of carbohydrate, glycemic index, and glycemic load and colorectal cancer risk, up to October 2011. Summary relative risks were estimated by the use of a random effects model.

Results

We identified 14 cohort studies that could be included in the meta-analysis of carbohydrate, glycemic index, and glycemic load and colorectal cancer risk. The summary RR for high versus low intake was 1.00 (95% CI: 0.87–1.14, I2 = 31%) for carbohydrate, 1.07 (95% CI: 0.99–1.16, I2 = 28%) for glycemic index, and 1.00 (95% CI: 0.91–1.10, I2 = 39%) for glycemic load. In the dose–response analysis, the summary RR was 0.95 (95% CI: 0.84–1.07, I2 = 58%) per 100 grams of carbohydrate per day, 1.07 (95% CI: 0.99–1.15, I2 = 39%) per 10 glycemic index units, and 1.01 (95% CI: 0.95–1.08, I2 = 47%) per 50 glycemic load units. Exclusion of one or two outlying studies reduced the heterogeneity, but the results were similar.

Conclusion

This meta-analysis of cohort studies does not support an independent association between diets high in carbohydrate, glycemic index, or glycemic load and colorectal cancer risk.

Keywords

CarbohydrateGlycemic indexGlycemic loadColorectal cancerMeta-analysis

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • D. Aune
    • 1
  • D. S. M. Chan
    • 1
  • R. Lau
    • 1
  • R. Vieira
    • 1
  • D. C. Greenwood
    • 2
  • E. Kampman
    • 3
  • T. Norat
    • 1
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthImperial College LondonLondonUK
  2. 2.Biostatistics Unit, Centre for Epidemiology and BiostatisticsUniversity of LeedsLeedsUK
  3. 3.Division of Human NutritionWageningen University and Research CentreWageningenThe Netherlands