Cancer Causes & Control

, Volume 24, Issue 3, pp 427–438

Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

  • Fatemeh Saberi Hosnijeh
  • Isabelle Romieu
  • Valentina Gallo
  • Elio Riboli
  • Anne Tjønneland
  • Jytte Halkjær
  • Guy Fagherazzi
  • Françoise Clavel-Chapelon
  • Laure Dossus
  • Annie Lukanova
  • Rudolf Kaaks
  • Antonia Trichopoulou
  • Pagona Lagiou
  • Michael Katsoulis
  • Salvatore Panico
  • Giovanna Tagliabue
  • Catalina Bonet
  • Miren Dorronsoro
  • José María Huerta
  • Eva Ardanaz
  • Maria-José Sánchez
  • Dorthe Johansen
  • Signe Borgquist
  • Petra Peeters
  • H. Bas Bueno-de-Mesquita
  • Martine M. Ros
  • Ruth C. Travis
  • Timothy J. Key
  • Paolo Vineis
  • Roel Vermeulen
Original paper

DOI: 10.1007/s10552-012-0128-2

Cite this article as:
Saberi Hosnijeh, F., Romieu, I., Gallo, V. et al. Cancer Causes Control (2013) 24: 427. doi:10.1007/s10552-012-0128-2

Abstract

Purpose

Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC).

Methods

During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia.

Results

No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height.

Conclusion

The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed.

Keywords

LeukemiaMyeloidLymphoidAnthropometryBody mass indexCohort studies

Supplementary material

10552_2012_128_MOESM1_ESM.doc (34 kb)
Supplementary material 1 (DOC 34 kb)
10552_2012_128_MOESM2_ESM.doc (88 kb)
Supplementary material 2 (DOC 87 kb)
10552_2012_128_MOESM3_ESM.doc (37 kb)
Supplementary material 3 (DOC 37 kb)
10552_2012_128_MOESM4_ESM.doc (57 kb)
Supplementary material 4 (DOC 57 kb)
10552_2012_128_MOESM5_ESM.doc (116 kb)
Supplementary material 5 (DOC 116 kb)

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Fatemeh Saberi Hosnijeh
    • 1
    • 2
  • Isabelle Romieu
    • 3
  • Valentina Gallo
    • 4
  • Elio Riboli
    • 4
  • Anne Tjønneland
    • 5
  • Jytte Halkjær
    • 5
  • Guy Fagherazzi
    • 6
    • 7
  • Françoise Clavel-Chapelon
    • 6
    • 7
  • Laure Dossus
    • 6
    • 7
  • Annie Lukanova
    • 8
  • Rudolf Kaaks
    • 8
  • Antonia Trichopoulou
    • 9
    • 10
  • Pagona Lagiou
    • 9
    • 11
  • Michael Katsoulis
    • 10
  • Salvatore Panico
    • 12
  • Giovanna Tagliabue
    • 13
  • Catalina Bonet
    • 14
  • Miren Dorronsoro
    • 15
  • José María Huerta
    • 16
    • 17
  • Eva Ardanaz
    • 17
    • 18
  • Maria-José Sánchez
    • 17
    • 19
  • Dorthe Johansen
    • 20
  • Signe Borgquist
    • 21
  • Petra Peeters
    • 22
  • H. Bas Bueno-de-Mesquita
    • 23
    • 24
  • Martine M. Ros
    • 23
    • 25
  • Ruth C. Travis
    • 26
  • Timothy J. Key
    • 26
  • Paolo Vineis
    • 4
  • Roel Vermeulen
    • 1
    • 22
  1. 1.Division Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS)Utrecht UniversityUtrechtNetherlands
  2. 2.Zanjan University of Medical ScienceZanjanIran
  3. 3.International Agency for Research on Cancer (IARC-WHO)LyonFrance
  4. 4.Division of Epidemiology, Public Health and Primary Care, Faculty of MedicineImperial CollegeLondonUK
  5. 5.Danish Cancer Society Research CenterCopenhagenDenmark
  6. 6.Inserm, U1018Gustave Roussy InstituteVillejuifFrance
  7. 7.Paris South University, UMRS 1018VillejuifFrance
  8. 8.Division of Cancer EpidemiologyGerman Cancer Research CentreHeidelbergGermany
  9. 9.Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition PoliciesUniversity of Athens Medical SchoolAthensGreece
  10. 10.Hellenic Health FoundationAthensGreece
  11. 11.Bureau of Epidemiologic Research, Academy of AthensAthensGreece
  12. 12.Department of Clinical and Experimental Medicine Federico II UniversityNaplesItaly
  13. 13.Environmental Epidemiology and Cancer Registry UnitFondazione IRCCS Istituto Nazionale dei TumoriMilanItaly
  14. 14.Unit of Nutrition, Environment and CancerCatalan Institute of Oncology (ICO)BarcelonaSpain
  15. 15.Public Health Division of Gipuzkoa, Basque Regional Health Department and Biodonostia/CiberespSan SebastiánSpain
  16. 16.Department of EpidemiologyMurcia Regional Health AuthorityMurciaSpain
  17. 17.CIBER Epidemiología y Salud Pública (CIBERESP)PamplonaSpain
  18. 18.Navarre Public Health InstitutePamplonaSpain
  19. 19.Andalusian School of Public HealthGranadaSpain
  20. 20.Department of Surgery, Malmö University HospitalLund UniversityMalmöSweden
  21. 21.Clinical Sciences, Department of OncologyLund UniversityLundSweden
  22. 22.Julius Center for Health Sciences and Primary CareUniversity Medical CenterUtrechtNetherlands
  23. 23.National Institute for Public Health and the Environment (RIVM)BilthovenThe Netherlands
  24. 24.Department of Gastroenterology and HepatologyUniversity Medical CentreUtrechtThe Netherlands
  25. 25.Department of Epidemiology, Biostatistics and HTARadboud University Nijmegen Medical CentreNijmegenThe Netherlands
  26. 26.Cancer Epidemiology Unit, Nuffield Department of Clinical MedicineUniversity of OxfordOxfordUK