Cancer Causes & Control

, Volume 24, Issue 1, pp 71–79

A population-based analysis of the effect of marital status on overall and cancer-specific mortality in patients with squamous cell carcinoma of the penis

  • Rodolphe Thuret
  • Maxine Sun
  • Lars Budaus
  • Firas Abdollah
  • Daniel Liberman
  • Shahrokh F. Shariat
  • François Iborra
  • Jacques Guiter
  • Jean-Jacques Patard
  • Paul Perrotte
  • Pierre I. Karakiewicz
Original paper

DOI: 10.1007/s10552-012-0091-y

Cite this article as:
Thuret, R., Sun, M., Budaus, L. et al. Cancer Causes Control (2013) 24: 71. doi:10.1007/s10552-012-0091-y

Abstract

Purpose

The association between marital status and tumor stage and grade, as well as overall mortality (OM) and cancer-specific mortality (CSM) received little attention in patients with squamous cell carcinoma of the penis (SCCP).

Methods

We relied on the surveillance, epidemiology, and end results (SEER) 17 database to identify patients diagnosed with primary SCCP. Logistic and Cox regression models, respectively, addressed the effect of marital status on the rate of locally advanced disease and its effect on OM and CSM. Covariates consisted of age, race, socioeconomic status, year of surgery, and SEER registries.

Results

Between 1988 and 2006, 1,884 patients with SCCP were identified. At surgery, 1,192 (63.3 %) were married and 966 (51.3 %) had locally advanced disease. In multivariable logistic regression models predicting locally advanced disease at surgery, unmarried men had a 1.5-fold higher (p < 0.001) risk than others. In multivariable Cox models predicting CSM, marital status had no effect [hazard ratio (HR) = 1.3, p = 0.1]. Finally, in multivariable Cox models predicting OM, unmarried men had a 1.3-fold higher (p = 0.001) risk than others.

Conclusion

Unmarried men tend to present with less favorable disease stage at SCCP. Moreover, unmarried men tend to live less long than their married counterparts. However, marital status has no effect on CSM.

Keywords

Penile carcinomaMarital statusSurveillance, epidemiology, and end results (SEER) program

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Rodolphe Thuret
    • 1
    • 2
  • Maxine Sun
    • 1
  • Lars Budaus
    • 1
    • 2
    • 3
  • Firas Abdollah
    • 1
    • 2
    • 3
    • 4
  • Daniel Liberman
    • 1
    • 2
    • 3
    • 4
    • 5
  • Shahrokh F. Shariat
    • 6
  • François Iborra
    • 2
  • Jacques Guiter
    • 2
  • Jean-Jacques Patard
    • 7
  • Paul Perrotte
    • 5
  • Pierre I. Karakiewicz
    • 1
    • 2
    • 3
    • 4
    • 5
  1. 1.Cancer Prognostics and Health Outcomes UnitUniversity of MontrealMontrealCanada
  2. 2.Department of UrologyMontpellier UniversityMontpellierFrance
  3. 3.Martini-ClinicProstate Cancer Center Hamburg-EppendorfHamburgGermany
  4. 4.Department of UrologyVita-Salute San Raffaele UniversityMilanItaly
  5. 5.Department of UrologyUniversity of MontrealMontrealCanada
  6. 6.Department of UrologyWeill Medical College of Cornell UniversityNew YorkUSA
  7. 7.Department of UrologyKremlin-Bicetre’s HospitalParisFrance