Original paper

Cancer Causes & Control

, Volume 24, Issue 1, pp 71-79

A population-based analysis of the effect of marital status on overall and cancer-specific mortality in patients with squamous cell carcinoma of the penis

  • Rodolphe ThuretAffiliated withCancer Prognostics and Health Outcomes Unit, University of MontrealDepartment of Urology, Montpellier University Email author 
  • , Maxine SunAffiliated withCancer Prognostics and Health Outcomes Unit, University of Montreal
  • , Lars BudausAffiliated withCancer Prognostics and Health Outcomes Unit, University of MontrealDepartment of Urology, Montpellier UniversityMartini-Clinic, Prostate Cancer Center Hamburg-Eppendorf
  • , Firas AbdollahAffiliated withCancer Prognostics and Health Outcomes Unit, University of MontrealDepartment of Urology, Montpellier UniversityMartini-Clinic, Prostate Cancer Center Hamburg-EppendorfDepartment of Urology, Vita-Salute San Raffaele University
  • , Daniel LibermanAffiliated withCancer Prognostics and Health Outcomes Unit, University of MontrealDepartment of Urology, Montpellier UniversityMartini-Clinic, Prostate Cancer Center Hamburg-EppendorfDepartment of Urology, Vita-Salute San Raffaele UniversityDepartment of Urology, University of Montreal
  • , Shahrokh F. ShariatAffiliated withDepartment of Urology, Weill Medical College of Cornell University
  • , François IborraAffiliated withDepartment of Urology, Montpellier University
  • , Jacques GuiterAffiliated withDepartment of Urology, Montpellier University
  • , Jean-Jacques PatardAffiliated withDepartment of Urology, Kremlin-Bicetre’s Hospital
    • , Paul PerrotteAffiliated withDepartment of Urology, University of Montreal
    • , Pierre I. KarakiewiczAffiliated withCancer Prognostics and Health Outcomes Unit, University of MontrealDepartment of Urology, Montpellier UniversityMartini-Clinic, Prostate Cancer Center Hamburg-EppendorfDepartment of Urology, Vita-Salute San Raffaele UniversityDepartment of Urology, University of Montreal

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Abstract

Purpose

The association between marital status and tumor stage and grade, as well as overall mortality (OM) and cancer-specific mortality (CSM) received little attention in patients with squamous cell carcinoma of the penis (SCCP).

Methods

We relied on the surveillance, epidemiology, and end results (SEER) 17 database to identify patients diagnosed with primary SCCP. Logistic and Cox regression models, respectively, addressed the effect of marital status on the rate of locally advanced disease and its effect on OM and CSM. Covariates consisted of age, race, socioeconomic status, year of surgery, and SEER registries.

Results

Between 1988 and 2006, 1,884 patients with SCCP were identified. At surgery, 1,192 (63.3 %) were married and 966 (51.3 %) had locally advanced disease. In multivariable logistic regression models predicting locally advanced disease at surgery, unmarried men had a 1.5-fold higher (p < 0.001) risk than others. In multivariable Cox models predicting CSM, marital status had no effect [hazard ratio (HR) = 1.3, p = 0.1]. Finally, in multivariable Cox models predicting OM, unmarried men had a 1.3-fold higher (p = 0.001) risk than others.

Conclusion

Unmarried men tend to present with less favorable disease stage at SCCP. Moreover, unmarried men tend to live less long than their married counterparts. However, marital status has no effect on CSM.

Keywords

Penile carcinoma Marital status Surveillance, epidemiology, and end results (SEER) program