Cancer Causes & Control

, Volume 23, Issue 2, pp 245–254

Case–control study of smoking and non-melanoma skin cancer

  • Dana E. Rollison
  • Michelle R. Iannacone
  • Jane L. Messina
  • L. Frank  Glass
  • Anna R. Giuliano
  • Richard G. Roetzheim
  • Basil S. Cherpelis
  • Neil A. Fenske
  • Kristen A. Jonathan
  • Vernon K. Sondak
Original paper

DOI: 10.1007/s10552-011-9872-y

Cite this article as:
Rollison, D.E., Iannacone, M.R., Messina, J.L. et al. Cancer Causes Control (2012) 23: 245. doi:10.1007/s10552-011-9872-y

Abstract

Objective

To investigate the association between cigarette smoking and basal and squamous cell carcinomas (BCC and SCC) of the skin, a clinic-based case–control study was conducted in Tampa, FL.

Methods

Patients with histologically confirmed BCC/SCC were recruited from a university dermatology clinic (n = 215 BCC, 165 SCC). Controls were comprised of individuals with no history of skin cancer who screened negative for skin cancer upon physical examination at the affiliated cancer screening or primary care clinics (n = 315). Information on smoking and other risk factors was obtained from self-administered questionnaires.

Results

After adjustment for age, sex, and other skin cancer–risk factors, ever smoking was not associated with BCC (odds ratio (OR) = 1.26, 95% confidence interval (CI) = 0.83–1.92), but was statistically significantly associated with SCC (OR = 1.97, 95% CI = 1.19–3.26), with significant trends observed for SCC associated with increasing cigarettes per day (p = 0.01) and pack-years smoked (p = 0.01). Among men, smoking ≥20 pack-years was associated with non-significant increased risks of BCC (OR = 1.90, 95% CI = 0.88–4.12) and SCC (OR = 1.97, 95% CI = 0.84–4.66), whereas among women, no association was observed with BCC (OR = 0.98, 95% CI = 0.39–2.46) while a statistically significant three-fold risk was observed with SCC (OR = 3.00, 95% CI = 1.02–8.80).

Conclusion

Cigarette smoking is more strongly associated with SCC than BCC, particularly among women.

Keywords

SmokingTobaccoNon-melanoma skin cancerBasal cell carcinomaSquamous cellCarcinomaCase–control

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Dana E. Rollison
    • 1
  • Michelle R. Iannacone
    • 1
  • Jane L. Messina
    • 2
    • 3
    • 4
  • L. Frank  Glass
    • 3
    • 4
  • Anna R. Giuliano
    • 1
  • Richard G. Roetzheim
    • 5
  • Basil S. Cherpelis
    • 4
  • Neil A. Fenske
    • 3
    • 4
  • Kristen A. Jonathan
    • 1
  • Vernon K. Sondak
    • 2
  1. 1.Department of Cancer EpidemiologyMoffitt Cancer CenterTampaUSA
  2. 2.Cutaneous Oncology ProgramMoffitt Cancer CenterTampaUSA
  3. 3.Department of Pathology and Cell BiologyUniversity of South Florida (USF) College of MedicineTampaUSA
  4. 4.Department of Dermatology and Cutaneous SurgeryUSF College of MedicineTampaUSA
  5. 5.Department of Family MedicineUSF College of MedicineTampaUSA