Cancer Causes & Control

, 22:1691

Patterns of meat intake and risk of prostate cancer among African-Americans in a large prospective study

  • Jacqueline M. Major
  • Amanda J. Cross
  • Joanne L. Watters
  • Albert R. Hollenbeck
  • Barry I. Graubard
  • Rashmi Sinha
Original paper

DOI: 10.1007/s10552-011-9845-1

Cite this article as:
Major, J.M., Cross, A.J., Watters, J.L. et al. Cancer Causes Control (2011) 22: 1691. doi:10.1007/s10552-011-9845-1

Abstract

Objective

Given the large racial differences in prostate cancer risk, further investigation of diet and prostate cancer is warranted among high-risk groups. The purpose of this study was to examine the association between type of meat intake and prostate cancer risk among African-American men.

Methods

In the large, prospective NIH-AARP Diet and Health Study, we analyzed baseline (1995–1996) data from African-American participants, aged 50–71 years. Incident prostate cancer cases (n = 1,089) were identified through 2006. Dietary and risk factor data were ascertained by questionnaires administered at baseline. Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) within intake quantiles.

Results

Neither white nor processed meat intake was associated with prostate cancer, regardless of meat-cooking method. Red meats cooked at high temperatures were associated with an increased risk of prostate cancer (HR = 1.18, 95% CI = 1.00–1.38 and HR = 1.22, 95% CI = 1.03–1.44, for the upper two intake tertiles). Intake of the heterocyclic amine (HCA), 2-amino-3,4,8-trimethylimidazo[4,5-f] quinoxaline (DiMeIQx) was positively associated with prostate cancer (HR = 1.30; 95% CI = 1.05–1.61, p = 0.02). No associations were observed for intake of other HCAs.

Conclusion

Red meats cooked at high temperatures were positively associated with prostate cancer risk among African-American men. Further studies are needed to replicate these findings.

Keywords

Prostate cancerCohort studiesDietMeat consumptionRacial disparitiesMen

Copyright information

© Springer Science+Business Media B.V. (outside the USA)  2011

Authors and Affiliations

  • Jacqueline M. Major
    • 1
  • Amanda J. Cross
    • 1
  • Joanne L. Watters
    • 2
  • Albert R. Hollenbeck
    • 3
  • Barry I. Graubard
    • 1
  • Rashmi Sinha
    • 1
  1. 1.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human ServicesRockvilleUSA
  2. 2.Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Department of Health and Human ServicesRockvilleUSA
  3. 3.AARPWashingtonUSA