Cancer Causes & Control

, 22:1545

Serum total and HDL cholesterol and risk of prostate cancer

  • Alison M. Mondul
  • Stephanie J. Weinstein
  • Jarmo Virtamo
  • Demetrius Albanes
Original paper

DOI: 10.1007/s10552-011-9831-7

Cite this article as:
Mondul, A.M., Weinstein, S.J., Virtamo, J. et al. Cancer Causes Control (2011) 22: 1545. doi:10.1007/s10552-011-9831-7

Abstract

Background

Studies suggest a decreased risk of high-grade prostate cancer in men with lower circulating total cholesterol and that statins may protect against aggressive disease. Confirmation in additional populations and examination of associations for lipoprotein subfractions are needed.

Methods

We examined prostate cancer risk and serum total and HDL cholesterol in the ATBC Study cohort (n = 29,093). Cox proportional hazards models were used to estimate the relative risk of total (n = 2,041), non-aggressive (n = 829), aggressive (n = 461), advanced (n = 412), and high-grade (n = 231) prostate cancer by categories of total and HDL cholesterol.

Results

After excluding the first 10 years of follow-up, men with higher serum total cholesterol were at increased risk of overall (≥240 vs. <200 mg/dl: HR = 1.22, 95% CI 1.03–1.44, p-trend = 0.01) and advanced (≥240 vs. <200 mg/dl: HR = 1.85, 95% CI 1.13–3.03, p-trend = 0.05) prostate cancer. Higher HDL cholesterol was suggestively associated with a decreased risk of prostate cancer regardless of stage or grade.

Conclusions

In this population of smokers, high serum total cholesterol was associated with higher risk of advanced prostate cancer, and high HDL cholesterol suggestively reduced the risk of prostate cancer overall. These results support previous studies and, indirectly, support the hypothesis that statins may reduce the risk of advanced prostate cancer by lowering cholesterol.

Keywords

CholesterolHDLProspective studiesProstatic neoplasmsEpidemiologyRiskMolecularBiomarker

Copyright information

© Springer Science+Business Media B.V. (outside the USA)  2011

Authors and Affiliations

  • Alison M. Mondul
    • 1
  • Stephanie J. Weinstein
    • 1
  • Jarmo Virtamo
    • 2
  • Demetrius Albanes
    • 1
  1. 1.Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute, NIHRockvilleUSA
  2. 2.Department of Chronic Disease PreventionNational Institute for Health and WelfareHelsinkiFinland