Cancer Causes & Control

, 22:1061

Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study

Authors

    • Epidemiology BranchNational Institute of Environmental Health Sciences
  • Dale P. Sandler
    • Epidemiology BranchNational Institute of Environmental Health Sciences
  • Gleta Carswell
    • Laboratory of Molecular CarcinogenesisNational Institute of Environmental Health Sciences
  • Lisa A. De Roo
    • Epidemiology BranchNational Institute of Environmental Health Sciences
  • Christine G. Parks
    • Epidemiology BranchNational Institute of Environmental Health Sciences
  • Richard Cawthon
    • University of Utah
  • Clarice R. Weinberg
    • Biostatistics BranchNational Institute of Environmental Health Sciences
  • Jack A. Taylor
    • Epidemiology Branch, Laboratory of Molecular CarcinogenesisNational Institute of Environmental Health Sciences
Brief report

DOI: 10.1007/s10552-011-9778-8

Cite this article as:
Kim, S., Sandler, D.P., Carswell, G. et al. Cancer Causes Control (2011) 22: 1061. doi:10.1007/s10552-011-9778-8

Abstract

Objective

Telomeres are required for maintaining genomic integrity and may play a role in carcinogenesis. Some, but not all, epidemiologic studies have found that short telomeres in leukocytes are associated with an increased risk of breast cancer. To further elucidate this potential association, we examined telomere length in relation to breast cancer risk in prospectively collected blood samples from the Sister Study, a cohort of women aged 35–74 years who have a sister with breast cancer.

Methods

We performed a case-cohort analysis comparing incident breast cancer cases (n = 342) with a subcohort (n = 735), randomly selected from 29,026 participants, enrolled by June 1, 2007. Relative telomere length in peripheral blood cells was estimated using a single-tube monochrome multiplex quantitative PCR assay.

Results

No association was observed between telomere length and breast cancer risk. Compared with the longest quartile, hazard ratios (HR) associated with the second, third, and the shortest quartile were 0.91 [95% confidence interval (95% CI): 0.62–1.34], 1.11 (95% CI: 0.77–1.60), and 0.93 (95% CI: 0.64–1.35), respectively. Subgroup analyses by menopausal status, invasiveness, or estrogen receptor status of breast cancer did not reveal evidence of association between telomere length in blood cells and subsequent breast cancer risk.

Conclusions

This prospective investigation does not support telomere length in blood cells as a biomarker for breast cancer risk.

Keywords

Breast cancerTelomere lengthProspective studyBiomarkerqPCR

Copyright information

© Springer Science+Business Media B.V. (outside the USA) 2011