Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Telomeres are required for maintaining genomic integrity and may play a role in carcinogenesis. Some, but not all, epidemiologic studies have found that short telomeres in leukocytes are associated with an increased risk of breast cancer. To further elucidate this potential association, we examined telomere length in relation to breast cancer risk in prospectively collected blood samples from the Sister Study, a cohort of women aged 35–74 years who have a sister with breast cancer.
We performed a case-cohort analysis comparing incident breast cancer cases (n = 342) with a subcohort (n = 735), randomly selected from 29,026 participants, enrolled by June 1, 2007. Relative telomere length in peripheral blood cells was estimated using a single-tube monochrome multiplex quantitative PCR assay.
No association was observed between telomere length and breast cancer risk. Compared with the longest quartile, hazard ratios (HR) associated with the second, third, and the shortest quartile were 0.91 [95% confidence interval (95% CI): 0.62–1.34], 1.11 (95% CI: 0.77–1.60), and 0.93 (95% CI: 0.64–1.35), respectively. Subgroup analyses by menopausal status, invasiveness, or estrogen receptor status of breast cancer did not reveal evidence of association between telomere length in blood cells and subsequent breast cancer risk.
This prospective investigation does not support telomere length in blood cells as a biomarker for breast cancer risk.
- Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study
Cancer Causes & Control
Volume 22, Issue 7 , pp 1061-1066
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- Breast cancer
- Telomere length
- Prospective study
- Industry Sectors
- Author Affiliations
- 1. Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA
- 2. Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
- 3. University of Utah, Salt Lake City, UT, USA
- 4. Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
- 5. Epidemiology Branch, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA