Cancer Causes & Control

, Volume 22, Issue 7, pp 995–1002

Dietary carbohydrate, glycemic index, glycemic load, and risk of prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort

  • James M. Shikany
  • Andrew P. Flood
  • Cari M. Kitahara
  • Ann W. Hsing
  • Tamra E. Meyer
  • Bradley J. Willcox
  • David T. Redden
  • Regina G. Ziegler
Original paper

DOI: 10.1007/s10552-011-9772-1

Cite this article as:
Shikany, J.M., Flood, A.P., Kitahara, C.M. et al. Cancer Causes Control (2011) 22: 995. doi:10.1007/s10552-011-9772-1

Abstract

Objective

To evaluate the associations between dietary carbohydrate, glycemic index (GI), glycemic load (GL), and incident prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort.

Methods

Between September 1993 and September 2000, 38,343 men were randomized to the screening arm of the trial at one of 10 PLCO centers. A food frequency questionnaire administered at baseline assessed usual dietary intake over the preceding 12 months. Prostate cancer was ascertained by medical follow-up of suspicious screening results and annual mailed questionnaires and confirmed with medical records. Cox proportional hazards regression was used to model the associations of carbohydrate, GI, and GL with prostate cancer risk.

Results

During follow-up (median = 9.2 years), 2,436 incident prostate cancers were identified among 30,482 eligible participants. Overall, there were no associations of baseline carbohydrate, GI, or GL with incident prostate cancer in minimally or fully adjusted models. There were no associations when the 228 advanced and 2,208 non-advanced cancers were analyzed separately.

Conclusions

Dietary carbohydrate, GI, and GL were not associated with incident prostate cancer in PLCO. The narrow range of GI in this cohort may have limited our ability to detect associations, an issue that future studies should address.

Keywords

Prostatic neoplasms Dietary carbohydrates Glycemic index 

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • James M. Shikany
    • 1
  • Andrew P. Flood
    • 2
  • Cari M. Kitahara
    • 3
  • Ann W. Hsing
    • 3
  • Tamra E. Meyer
    • 3
  • Bradley J. Willcox
    • 4
  • David T. Redden
    • 5
  • Regina G. Ziegler
    • 3
  1. 1.Division of Preventive Medicine, School of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Division of Epidemiology and Community Health, Department of Food Science and NutritionUniversity of MinnesotaSt. PaulUSA
  3. 3.Division of Cancer Epidemiology and GeneticsNational Cancer Institute, National Institutes of HealthRockvilleUSA
  4. 4.Pacific Health Research InstituteThe Queen’s Medical CenterHonoluluUSA
  5. 5.Department of Biostatistics, School of Public HealthUniversity of Alabama at BirminghamBirminghamUSA

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