Cancer Causes & Control

, Volume 22, Issue 6, pp 885–897

Early-life sun exposure and risk of melanoma before age 40 years

Authors

    • Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population HealthUniversity of Melbourne
    • Cancer Epidemiology and Services Research (CESR), Sydney School of Public Health, Sydney Medical SchoolThe University of Sydney
  • Mark A. Jenkins
    • Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population HealthUniversity of Melbourne
  • Chris Goumas
    • Cancer Epidemiology and Services Research (CESR), Sydney School of Public Health, Sydney Medical SchoolThe University of Sydney
  • Bruce K. Armstrong
    • Cancer Epidemiology and Services Research (CESR), Sydney School of Public Health, Sydney Medical SchoolThe University of Sydney
  • Helen Schmid
    • Westmead Institute for Cancer Research, Millennium Institute and Melanoma Institute AustraliaUniversity of Sydney at Westmead
  • Joanne F. Aitken
    • Viertel Centre for Research in Cancer ControlCancer Council Queensland
  • Graham G. Giles
    • Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population HealthUniversity of Melbourne
    • Cancer Epidemiology CentreCancer Council Victoria
  • Richard F. Kefford
    • Westmead Institute for Cancer Research, Millennium Institute and Melanoma Institute AustraliaUniversity of Sydney at Westmead
  • John L. Hopper
    • Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population HealthUniversity of Melbourne
  • Graham J. Mann
    • Westmead Institute for Cancer Research, Millennium Institute and Melanoma Institute AustraliaUniversity of Sydney at Westmead
Original paper

DOI: 10.1007/s10552-011-9762-3

Cite this article as:
Cust, A.E., Jenkins, M.A., Goumas, C. et al. Cancer Causes Control (2011) 22: 885. doi:10.1007/s10552-011-9762-3

Abstract

Objective

To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39 years.

Methods

Data were analysed from 606 cases and 481 controls from the Australian Melanoma Family Study, a population-based, case–control-family study. Self- and parent-reported sun exposure was collected by interview. Odds ratios (OR) were estimated using unconditional logistic regression, adjusted for potential confounders.

Results

Self-reported childhood total sun exposure was not associated with melanoma overall, but was positively associated with melanoma diagnosed at 18–29 years of age (OR for highest vs. lowest quartile: 3.21, 95% confidence intervals (CI) 1.38–7.44; Ptrend 0.02; Pinteraction by age group 0.09). Analyses restricted to participants whose self-reported sun exposure was concordant with that recalled by their parents gave an OR for the highest versus lowest tertile of childhood total sun exposure of 2.28 (95% CI 1.03–5.04; Ptrend 0.05), and for any versus no severe childhood sunburn of 2.36 (95% CI 1.05–5.31). The association of self-reported severe sunburn with melanoma was evident only in people who tended to tan rather than burn and in people who had few nevi.

Conclusion

The association of early-life sun exposure with early-onset melanoma is influenced by host factors.

Keywords

MelanomaSun exposureEarly-onsetSunburn

Abbreviations

UV

Ultraviolet

Copyright information

© Springer Science+Business Media B.V. 2011