Cancer Causes & Control

, Volume 22, Issue 4, pp 589–598

Postdiagnosis diet quality, the combination of diet quality and recreational physical activity, and prognosis after early-stage breast cancer

Authors

    • Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute
    • Division of Chronic Disease EpidemiologyYale School of Public Health
  • Melinda L. Irwin
    • Division of Chronic Disease EpidemiologyYale School of Public Health
  • Ashley W. Smith
    • Applied Research Program, Division of Cancer Control and Population SciencesNational Cancer Institute
  • Marian L. Neuhouser
    • Division of Public Health SciencesFred Hutchinson Cancer Research Center
  • Jill Reedy
    • Applied Research Program, Division of Cancer Control and Population SciencesNational Cancer Institute
  • Anne McTiernan
    • Division of Public Health SciencesFred Hutchinson Cancer Research Center
  • Catherine M. Alfano
    • Office of Cancer Survivorship, Division of Cancer Control and Population SciencesNational Cancer Institute
  • Leslie Bernstein
    • Department of Population SciencesCity of Hope Medical Center and Beckman Research Center
  • Cornelia M. Ulrich
    • Division of Public Health SciencesFred Hutchinson Cancer Research Center
    • German Cancer Research Center and National Center for Tumor Diseases
  • Kathy B. Baumgartner
    • Department of Epidemiology and Population HealthUniversity of Louisville
  • Steven C. Moore
    • Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute
  • Demetrius Albanes
    • Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute
  • Susan T. Mayne
    • Division of Chronic Disease EpidemiologyYale School of Public Health
  • Mitchell H. Gail
    • Biostatistics Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute
  • Rachel Ballard-Barbash
    • Applied Research Program, Division of Cancer Control and Population SciencesNational Cancer Institute
Original paper

DOI: 10.1007/s10552-011-9732-9

Cite this article as:
George, S.M., Irwin, M.L., Smith, A.W. et al. Cancer Causes Control (2011) 22: 589. doi:10.1007/s10552-011-9732-9

Abstract

Objective

To investigate, among women with breast cancer, how postdiagnosis diet quality and the combination of diet quality and recreational physical activity are associated with prognosis.

Methods

This multiethnic, prospective observational cohort included 670 women diagnosed with local or regional breast cancer. Thirty months after diagnosis, women completed self-report assessments on diet and physical activity and were followed for 6 years. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals for death from any cause and breast cancer death.

Results

Women consuming better-quality diets, as defined by higher Healthy Eating Index-2005 scores, had a 60% reduced risk of death from any cause (HRQ4:Q1: 0.40, 95% CI: 0.17, 0.94) and an 88% reduced risk of death from breast cancer (HRQ4:Q1: 0.12, 95% CI: 0.02, 0.99). Compared with inactive survivors consuming poor-quality diets, survivors engaging in any recreational physical activity and consuming better-quality diets had an 89% reduced risk of death from any cause (HR: 0.11, 95% CI: 0.04, 0.36) and a 91% reduced risk of death from breast cancer (HR: 0.09, 95% CI: 0.01, 0.89). Associations observed were independent of obesity status.

Conclusion

Women diagnosed with localized or regional breast cancer may improve prognosis by adopting better-quality dietary patterns and regular recreational physical activity. Lifestyle interventions emphasizing postdiagnosis behavior changes are advisable in breast cancer survivors.

Keywords

DietExerciseBreast neoplasmPrognosis

Copyright information

© Springer Science+Business Media B.V. (outside the USA) 2011