Cancer Causes & Control

, Volume 22, Issue 3, pp 495–501

ASIP genetic variants and the number of non-melanoma skin cancers

  • Wen Lin
  • Abrar A. Qureshi
  • Peter Kraft
  • Hongmei Nan
  • Qun Guo
  • Frank B. Hu
  • Majken K. Jensen
  • Jiali Han
Original paper

DOI: 10.1007/s10552-010-9724-1

Cite this article as:
Lin, W., Qureshi, A.A., Kraft, P. et al. Cancer Causes Control (2011) 22: 495. doi:10.1007/s10552-010-9724-1

Abstract

Patients with primary non-melanoma skin cancers (NMSCs) tend to develop these cancers at multiple independent sites. We examined the genetic factors in the development of multiple NMSCs among Caucasian women with 28 years of follow-up. We initially evaluated 19 SNPs in nine pigmentation genes with the number of NMSCs in 492 cases and 619 controls without a history of NMSC. We found nominal significant associations between two ASIP gene–related SNPs, rs1885120 and rs910873, and an ASIP haplotype (AH) (rs4911414 allele T and rs1015362 allele G) and an increased number of NMSCs, with p-values of 0.008, 0.01, and 0.01, respectively. We further evaluated these two SNPs and AH haplotype in three data sets. In a joint analysis with 1,507 cases and 4,335 controls, AH haplotype was independently associated with the number of NMSCs with odds ratio (OR) (95% confidence interval (CI)) of 1.45(1.25–1.68) (p-value = 6.2E–07). The AH haplotype was associated with an increased risk of developing one NMSC (OR 1.32; 95% CI, 1.07–1.63). The OR increased to 1.45(1.18–1.78) for those with 2–4 NMSCs and 1.84(1.34–2.53) for those with at least five. The findings suggest that ASIP locus is associated with the number of NMSCs.

Keywords

SNPPigmentation geneNon-melanoma skin cancerASIP

Supplementary material

10552_2010_9724_MOESM1_ESM.doc (152 kb)
Supplementary material 1 (DOC 152 kb)

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Wen Lin
    • 1
  • Abrar A. Qureshi
    • 2
    • 3
  • Peter Kraft
    • 1
  • Hongmei Nan
    • 2
  • Qun Guo
    • 2
  • Frank B. Hu
    • 1
    • 2
    • 4
  • Majken K. Jensen
    • 4
  • Jiali Han
    • 1
    • 2
    • 3
  1. 1.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  2. 2.Channing Laboratory, Department of Medicine, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  3. 3.Clinical Research Program, Department of Dermatology, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  4. 4.Department of NutritionHarvard School of Public HealthBostonUSA