Cancer Causes & Control

, Volume 21, Issue 12, pp 2287–2293

Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis

Authors

    • Department of Public Health, Erasmus MCUniversity Medical Center Rotterdam
  • J. Dik F. Habbema
    • Department of Public Health, Erasmus MCUniversity Medical Center Rotterdam
  • Scott D. Ramsey
    • Fred Hutchinson Cancer Research Center
    • University of Washington
  • Rob Boer
    • Department of Public Health, Erasmus MCUniversity Medical Center Rotterdam
  • Caspar W. N. Looman
    • Department of Public Health, Erasmus MCUniversity Medical Center Rotterdam
  • Marjolein van Ballegooijen
    • Department of Public Health, Erasmus MCUniversity Medical Center Rotterdam
Original paper

DOI: 10.1007/s10552-010-9654-y

Cite this article as:
Wilschut, J.A., Habbema, J.D.F., Ramsey, S.D. et al. Cancer Causes Control (2010) 21: 2287. doi:10.1007/s10552-010-9654-y

Abstract

Objective

It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.

Methods

We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder.

Results

Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4–3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05–1.07). The age trend did not differ significantly between the two groups.

Conclusion

Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.

Keywords

Adenoma prevalenceFamily historyColorectal cancer

Copyright information

© Springer Science+Business Media B.V. 2010