Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis
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- Wilschut, J.A., Habbema, J.D.F., Ramsey, S.D. et al. Cancer Causes Control (2010) 21: 2287. doi:10.1007/s10552-010-9654-y
It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.
We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder.
Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4–3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05–1.07). The age trend did not differ significantly between the two groups.
Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.