Cancer Causes & Control

, Volume 21, Issue 12, pp 2183–2194

Physical activity, body size and composition, and risk of ovarian cancer

  • Fiona Chionh
  • Laura Baglietto
  • Kavitha Krishnan
  • Dallas R. English
  • Robert J. MacInnis
  • Dorota M. Gertig
  • John L. Hopper
  • Graham G. Giles
Original paper

DOI: 10.1007/s10552-010-9638-y

Cite this article as:
Chionh, F., Baglietto, L., Krishnan, K. et al. Cancer Causes Control (2010) 21: 2183. doi:10.1007/s10552-010-9638-y

Abstract

Objectives

We examined the association between risk of ovarian cancer and physical activity and anthropometry (body mass index, height, waist, fat, and fat-free mass) in the Melbourne Collaborative Cohort Study.

Methods

This prospective cohort study included 18,700 women aged 26–76 years old at recruitment between 1990 and 1994. Participants were interviewed about their physical activity, including frequency and intensity. Body measurements were taken directly; fat mass and fat-free mass were calculated from bioelectrical impedance analysis. During an average of 10.2 years of follow-up, 113 ovarian cancers were ascertained. Cox regression was used to estimate hazard ratios.

Results

After adjusting for potential confounders, compared with no physical activity, the hazard ratios for levels of total physical activity were 1.56 (95% CI: 0.81, 3.00) for low level, 1.92 (1.07, 3.45) for medium level, and 2.21 (1.16, 4.24) for high level (test for trend, p = 0.01). The hazard ratio for ovarian cancer in relation to BMI was 1.22 (95% CI: 1.00, 1.48; p-trend, 0.06) per 5 kg/m2 increment, and for fat mass, 1.23 (95% CI: 1.01, 1.49; p-trend, 0.04) per 10 kg increment.

Conclusions

This study found some evidence for a possible relationship between higher levels of physical activity and body size and increased ovarian cancer risk.

Keywords

Physical activityAnthropometryOvarian cancerBody mass indexCohort study

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Fiona Chionh
    • 1
  • Laura Baglietto
    • 1
    • 2
  • Kavitha Krishnan
    • 1
  • Dallas R. English
    • 1
    • 2
  • Robert J. MacInnis
    • 1
    • 2
    • 3
  • Dorota M. Gertig
    • 4
  • John L. Hopper
    • 2
  • Graham G. Giles
    • 1
    • 2
  1. 1.Cancer Epidemiology CentreThe Cancer Council VictoriaCarltonAustralia
  2. 2.Centre for Genetic EpidemiologyUniversity of MelbourneMelbourneAustralia
  3. 3.Cancer Research UK Genetic Epidemiology UnitUniversity of CambridgeCambridgeUK
  4. 4.Victorian Cytology ServiceMelbourneAustralia