Cancer Causes & Control

, Volume 21, Issue 12, pp 2157–2164

Assessing environmental and occupational risk factors for lung cancer in Mexican–Americans

  • Michelle K. McHugh
  • Sumesh Kachroo
  • Mei Liu
  • Anthony M. D’AmelioJr.
  • Qiong Dong
  • Waun Ki Hong
  • Anthony J. Greisinger
  • Margaret R. Spitz
  • Carol J. Etzel
Original paper

DOI: 10.1007/s10552-010-9635-1

Cite this article as:
McHugh, M.K., Kachroo, S., Liu, M. et al. Cancer Causes Control (2010) 21: 2157. doi:10.1007/s10552-010-9635-1

Abstract

Background

We investigated environmental and occupational exposures and smoking history (while controlling for demographics) in a population of Mexican–American lung cancer cases and controls from the Houston metropolitan area.

Methods

Data were collected between 1991 and 2005 as part of an on-going multi-racial/ethnic, lung cancer case–control study. Cases included 212 Mexican–American lung cancer cases from UT MD Anderson Cancer Center. Controls (n = 328) were recruited from Houston’s largest multispecialty group practice and frequency matched to the cases by age (±5 years), sex, and ethnicity. Environmental and occupational factors were analyzed and odds ratios and 95% confidence intervals were calculated using logistic regression.

Results

We detected elevated risks of lung cancer associated with pesticide exposure and found conventional and antimicrobial (e.g., sterilizers, disinfectants, antiseptics) pesticides were associated with an increased risk of lung cancer in Mexican–Americans (conventional pesticides and antimicrobial pesticides combined: OR = 1.80, 95% CI 1.13–2.86; conventional pesticides: OR = 2.05, 95% CI 1.23–2.39; antimicrobial pesticides: OR = 2.48, 95% CI 1.46–4.21).

Conclusions

Although we found over a two-fold increased risk of lung cancer among Mexican–Americans for pesticides, we could not identify individual pesticides. Our findings are an important preliminary step in identifying factors that are specifically associated with lung cancer risk among Mexican Americans.

Keywords

Lung cancer Epidemiology Occupational and environmental risk factors Mexican Americans Pesticides Antimicrobial agents 

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Michelle K. McHugh
    • 1
  • Sumesh Kachroo
    • 1
    • 2
  • Mei Liu
    • 1
    • 2
  • Anthony M. D’AmelioJr.
    • 1
    • 3
  • Qiong Dong
    • 1
  • Waun Ki Hong
    • 4
  • Anthony J. Greisinger
    • 5
  • Margaret R. Spitz
    • 1
  • Carol J. Etzel
    • 1
  1. 1.Department of EpidemiologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.The University of Texas School of Public HealthHoustonUSA
  3. 3.Biomath/Biostatistics ProgramThe University of Texas Graduate School for Biomedical SciencesHoustonUSA
  4. 4.Division of Cancer MedicineThe University of Texas MD Anderson Cancer CenterHoustonUSA
  5. 5.Kelsey Research FoundationHoustonUSA

Personalised recommendations