Cancer Causes & Control

, Volume 21, Issue 9, pp 1451–1459

B-cell chronic lymphocytic leukemia risk in association with serum leptin and adiponectin: a case–control study in Greece

  • Maria Dalamaga
  • Bradley H. Crotty
  • Jessica Fargnoli
  • Evangelia Papadavid
  • Antigoni Lekka
  • Maria Triantafilli
  • Konstantinos Karmaniolas
  • Ilias Migdalis
  • Amalia Dionyssiou-Asteriou
  • Christos S. Mantzoros
Original paper

DOI: 10.1007/s10552-010-9573-y

Cite this article as:
Dalamaga, M., Crotty, B.H., Fargnoli, J. et al. Cancer Causes Control (2010) 21: 1451. doi:10.1007/s10552-010-9573-y

Abstract

Aim

Leptin and adiponectin are two well-studied adipokines in relation to malignancies. In this study, we examined the association between leptin/adiponectin and risk of B-cell chronic lymphocytic leukemia (B-CLL), as well as the relationships between adipokines and several established prognostic factors of B-CLL.

Methods

Ninety-five patients with incident B-CLL and 95 hospital controls matched on age and gender were studied between 2001 and 2007, and blood samples were collected. Leptin, total and high molecular weight adiponectin, and prognostic markers of B-CLL were determined.

Results

Cases had a higher body mass index (BMI) than controls (p = 0.01) and lower levels of leptin (p < 0.01). Significantly more cases than controls presented a family history of lymphohematopoietic cancer (LHC) (p = 0.01). Higher serum leptin levels were associated with lower risk of B-CLL adjusting for age, gender, family history of LHC, BMI and serum adiponectin; the multivariate odds ratio comparing highest to lowest tertile was 0.05 (95% CI 0.01–0.29, p trend < 0.001); Adiponectin was not significantly different between cases and controls.

Conclusion

Leptin was found to be inversely associated with risk of CLL but in contrast to prior studies of CLL and hematologic malignancies, this study found no significant association between CLL and adiponectin.

Keywords

Adiponectin Leptin Adipokine Chronic lymphocytic leukemia Obesity 

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Maria Dalamaga
    • 1
  • Bradley H. Crotty
    • 2
  • Jessica Fargnoli
    • 2
  • Evangelia Papadavid
    • 3
  • Antigoni Lekka
    • 4
  • Maria Triantafilli
    • 4
  • Konstantinos Karmaniolas
    • 5
  • Ilias Migdalis
    • 5
  • Amalia Dionyssiou-Asteriou
    • 1
  • Christos S. Mantzoros
    • 2
  1. 1.Department of Clinical Biochemistry, Medical School, University of Athens“Attikon” General University HospitalAthensGreece
  2. 2.Division of Endocrinology, Diabetes and MetabolismBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA
  3. 3.Division of Internal Medicine, Department of Dermatology, Medical School, University of Athens“Attikon” General University HospitalAthensGreece
  4. 4.Department of Laboratory HematologyNIMTS General HospitalAthensGreece
  5. 5.Department of Internal MedicineNIMTS General HospitalAthensGreece

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